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Debt - Narrative (Details)
 1 Months Ended 3 Months Ended 9 Months Ended
May 05, 2017
USD ($)
Sep. 30, 2019
USD ($)
day
$ / shares
May 31, 2017
USD ($)
Aug. 31, 2015
USD ($)
day
$ / shares
Sep. 30, 2019
USD ($)
$ / shares
Sep. 30, 2019
USD ($)
$ / shares
Dec. 31, 2018
USD ($)
Long-term debt              
Debt Instrument Additional Amount Available For Repurchase           $ 37,500,000  
Adjustments to additional paid in capital, equity component of convertible debt         $ 119,489,000 119,489,000  
Convertible debt | 3.00% Convertible senior notes due 2022              
Long-term debt              
Debt principal amount   $ 150,000,000   $ 150,000,000.0 $ 150,000,000 $ 150,000,000 $ 150,000,000
Interest rate ( as a percent )       3.00%      
Net proceeds from issuance of convertible notes       $ 145,400,000      
Trading days, number | day       20      
Consecutive trading days, period | day       30      
Stock price trigger   130.00%          
Business days, period       5 days      
Consecutive trading-day period       5 days      
Maximum product of the closing sale price of shares of the Company's common stock and the applicable conversion rate for such trading day   98.00%     98.00% 98.00%  
Conversion ratio       17.7487      
Conversion price per share (in dollars per share) | $ / shares       $ 56.34      
Convertible instruments principal and unpaid interest payable upon events of default   100.00%          
Minimum percentage of principal held by convertible debt instrument holders required to issue notice for declaration of principal and unpaid interest payable upon events of default   25.00%          
Adjustments to additional paid in capital, equity component of convertible debt       $ 57,500,000      
Net deferred tax liability in connection with convertible notes       $ 22,300,000      
Fair value of convertible notes   $ 156,400,000     $ 156,400,000 $ 156,400,000 $ 146,600,000
Remaining contractual life of the convertible notes           2 years 10 months 24 days  
Convertible debt | 3.00% Convertible senior notes due 2022 | Redemption on or after August 20, 2018              
Long-term debt              
Trading days, number | day   19          
Consecutive trading days, period | day   30          
Stock price trigger   130.00%          
Redemption price   100.00%          
Sinking fund   $ 0     0 $ 0  
Convertible debt | 1.50% Convertible senior notes due 2026              
Long-term debt              
Debt principal amount   $ 287,500,000     $ 287,500,000 $ 287,500,000  
Interest rate ( as a percent )   1.50%     1.50% 1.50%  
Net proceeds from issuance of convertible notes           $ 279,300,000  
Trading days, number | day   20          
Business days, period   5 days          
Consecutive trading-day period   5 days          
Conversion ratio   19.0404          
Conversion price per share (in dollars per share) | $ / shares   $ 52.52     $ 52.52 $ 52.52  
Term of the convertible notes   7 years   7 years      
Adjustments to additional paid in capital, equity component of convertible debt   $ 123,000,000.0          
Net deferred tax liability in connection with convertible notes   25,300,000     $ 25,300,000 $ 25,300,000  
Fair value of convertible notes   $ 273,800,000     $ 273,800,000 273,800,000  
MidCap Financial Trust              
Long-term debt              
Line of credit facility, maximum borrowing capacity     $ 60,000,000.0        
Proceeds from lines of credit $ 40,000,000.0            
Line of credit facility, additional capacity available, net product revenue threshold     20,000,000.0        
Debt issuance costs     $ 400,000        
Repayments of Debt           $ 6,700,000  
Debt instrument, floor interest rate     1.00%        
Debt instrument, basis spread on variable rate     6.15%        
Debt instrument, interest payment period     24 months