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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018
Stock Appreciation Rights (SARs) |  |
Changes in the fair value of warrant liability |  |
Beginning balance | $ 3,814 |
Ending balance | 3,186 | $ 3,814
Significant unobservable inputs (level 3) | Stock Appreciation Rights (SARs) |  |
Changes in the fair value of warrant liability |  |
Beginning balance | 3,814 | 1,665
Additions | 0 | 0
Change in fair value | 3,187 | 4,140
Payments | (3,815) | (1,991)
Ending balance | 3,186 | 3,814
Significant unobservable inputs (level 3) | Agilis |  |
Changes in the fair value of warrant liability |  |
Ending balance | 65,800 |
Liability, Development and Regulatory Milestone | Agilis |  |
Changes in the fair value of warrant liability |  |
Beginning balance | 257,040 |
Ending balance | 290,500 | 257,040
Liability, Development and Regulatory Milestone | Significant unobservable inputs (level 3) | BioElectron | Commitments |  |
Changes in the fair value of warrant liability |  |
Beginning balance | 257,040 | 0
Additions | 0 | 263,500
Change in fair value | 33,460 | (6,460)
Payments | 0 | 0
Ending balance | 290,500 | 257,040
Liability, Net Sales Milestones and Royalties | Agilis |  |
Changes in the fair value of warrant liability |  |
Beginning balance | 53,200 |
Ending balance | 65,800 | 53,200
Liability, Net Sales Milestones and Royalties | Significant unobservable inputs (level 3) | BioElectron |  |
Changes in the fair value of warrant liability |  |
Beginning balance | 53,200 | 0
Additions | 0 | 27,000
Change in fair value | 12,600 | 26,200
Payments | 0 | 0
Ending balance | $ 65,800 | $ 53,200

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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258 + Details
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