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Revenue recognition Recenue recognition - Roche and SMA Foundation (Details) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2019 USD ($) | Oct. 31, 2017 USD ($) | Nov. 30, 2014 USD ($) | Jan. 31, 2014 USD ($) | Aug. 31, 2013 USD ($) | Nov. 30, 2011 USD ($) compound | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) deliverable | Dec. 31, 2017 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Performance obligations satisfied in current period |  |  |  |  |  |  | $ 3,900 | $ 0 |
Revenue |  |  |  |  |  |  | 306,980 | 264,734 | $ 194,392
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Additions |  |  |  |  |  | $ 30,000 |  |  |
Performance obligations satisfied in current period | $ 15,000 | $ 20,000 | $ 10,000 | $ 7,500 | $ 10,000 |  |  |  |
Revenue |  |  |  |  |  |  | 15,200 | $ 200 | 20,300
Revenue, remaining performance obligation, amount |  |  |  |  |  | $ 30,000 |  |  |
Collaborative Arrangement | Roche And Sma Foundation |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Collaborative arrangements number of compounds in preclinical development | compound |  |  |  |  |  | 3 |  |  |
Collaborative arrangements number of significant deliverables | deliverable |  |  |  |  |  |  |  | 2 |
Research And Development Event Milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  | 135,000 |  |
Potential net sales milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  | 325,000 |  |
United States |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product sales |  |  |  |  |  |  | 101,000 | $ 92,000 | 28,800
Revenue |  |  |  |  |  |  | 116,676 | 93,694 |
Non-US |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product sales |  |  |  |  |  |  | 190,300 | 171,000 | $ 145,200
Revenue |  |  |  |  |  |  | $ 190,304 | $ 171,040 |

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