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Revenue recognition - Narrative (Details) $ in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2019 USD ($) | Oct. 31, 2017 USD ($) | Nov. 30, 2014 USD ($) | Jan. 31, 2014 USD ($) | Aug. 31, 2013 USD ($) | Nov. 30, 2011 USD ($) compound | Dec. 31, 2019 USD ($) segment Number_Distributor | Dec. 31, 2018 USD ($) deliverable | Dec. 31, 2017 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  |  |  |  |  | 1 |  |
Number of distributors | Number_Distributor |  |  |  |  |  |  | 3 |  |
Percentage of net product sales |  |  |  |  |  |  | 10.00% |  |
Contract with customer, liability |  |  |  |  |  |  | $ 11.7 | $ 12.9 |
Performance obligations satisfied in current period |  |  |  |  |  |  | 3.9 | 0.0 |
United States |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product sales |  |  |  |  |  |  | 101.0 | 92.0 | $ 28.8
Non-US |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product sales |  |  |  |  |  |  | 190.3 | 171.0 | 145.2
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Performance obligations satisfied in current period | $ 15.0 | $ 20.0 | $ 10.0 | $ 7.5 | $ 10.0 |  |  |  |
Additions |  |  |  |  |  | $ 30.0 |  |  |
Revenue, remaining performance obligation, amount |  |  |  |  |  | $ 30.0 |  |  |
Revenue, remaining performance obligation, expected timing of satisfaction, period |  |  |  |  |  | 2 years |  |  |
Revenue |  |  |  |  |  |  | 15.2 | $ 0.2 | $ 20.3
Collaborative Arrangement | Roche And Sma Foundation |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Collaborative arrangements number of compounds in preclinical development | compound |  |  |  |  |  | 3 |  |  |
Collaborative arrangements number of significant deliverables | deliverable |  |  |  |  |  |  |  | 2 |
Research And Development Event Milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, remaining milestone, potential achievements |  |  |  |  |  |  | 72.5 |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  | 135.0 |  |
Potential net sales milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  | $ 325.0 |  |

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