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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Operating loss carryforwards |  |  |
Valuation allowance | $ 267,131 | $ 180,481 |
Valuation allowance, deferred tax asset, increase (decrease) | 86,700 | $ 2,800 |
Deferred Tax Assets, Operating Loss Carryforwards | 231,500 |  |
Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 | 231,500 |  |
Orphan drug credit carryover | 85,200 |  |
Operating loss carryforwards, not subject to expiration | 169,200 |  |
Operating loss carryforwards, subject to expiration | 62,300 |  |
Operating loss carryforwards for immediate use | 333,200 |  |
Operating loss carryforwards in next twelve months | $ 5,700 |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 34.00%
Uncertain tax position | $ 0 |  |
First five years from ownership change |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 16,700 |  |
After five years |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 5,700 |  |
Federal |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 433,300 |  |
Research and development credit carryforwards | 14,200 |  |
Operating Loss Carryforwards, Available | 495,700 |  |
State |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 224,400 |  |
Research and development credit carryforwards | 6,200 |  |
Foreign Tax Authority |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | $ 8,400 |  |

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