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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
May 31, 2019 | Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Aug. 23, 2018 | Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Useful life |  |  |  | 7 years |  |  |  |
Amortization of acquired intangible asset |  |  |  | $ 27,650 | $ 22,877 | $ 15,380 |  |
Finite-Lived Intangible Assets, Remaining Amortization Period |  |  |  | 4 years 6 months |  |  |  |
Goodwill |  | $ 82,341 | $ 82,341 | $ 82,341 | 82,341 |  |  |
Goodwill adjustment |  | 18,000 |  |  |  |  |  |
Akcea |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Milestone, potential achievements, regulatory approval |  |  |  | $ 4,000 |  |  |  |
Upfront licensing fee | $ 6,000 |  |  |  | 12,000 |  |  |
Non-collaborative Arrangement Transactions | Akcea |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Useful life |  |  |  | 10 years |  |  |  |
Milestone, potential achievements, regulatory approval | $ 6,000 |  |  | $ 4,000 |  |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Intangibles assets of Emflaza |  |  |  |  |  |  |  | $ 148,373
Milestone, potential achievements, regulatory approval |  | 14,400 | 14,400 | 27,100 | 14,400 |  |  |
Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  | 11,400 |  |  |  |
Agilis |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  | 40,000 |  |  | $ 40,000 |
Goodwill |  | 82,341 | 82,341 | 82,300 | 82,341 |  | 100,309 |
Goodwill adjustment |  |  | (17,968) |  |  |  |  |
Agilis | Non-collaborative Arrangement Transactions |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  | 40,000 |  |  | 40,000 |
Intellectual Property |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Accumulated amortization |  |  |  | $ 65,900 |  |  |  |
In Process Research and Development [Member] | Agilis |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |
Intangible assets, other than goodwill |  | $ 576,500 | $ 576,500 |  | $ 576,500 |  | $ 480,000 |

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