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Summary of significant accounting policies - Narrative (Details) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2019 USD ($) segment | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jan. 01, 2019 USD ($) | Aug. 23, 2018 USD ($) | Jan. 01, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Letters of credit | $ 7,500,000 |  |  |  |  |
Term for letter of credit (in years) | 5 years |  |  |  |  |
Number of operating segments | segment | 1 |  |  |  |  |
Number of reporting units | segment | 1 |  |  |  |  |
Inventory write-down | $ 400,000 | $ 1,800,000 |  |  |  |
Operating lease ROU asset | 13,693,000 |  |  | $ 11,300,000 |  |
Accumulated deficit | (1,190,499,000) | (938,923,000) |  |  |  |
ASC 606 Adjustment | 3,900,000 |  |  |  |  |
Allowance for doubtful accounts | 300,000 | 700,000 |  |  |  |
Deferred research and development advance payments | $ 4,500,000 | $ 2,400,000 |  |  |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 34.00% |  |  |
Impairment of long-lived assets | $ 0 |  |  |  |  |
Operating lease, liability | 14,171,000 |  |  | $ 11,300,000 |  |
Agilis |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Deferred tax liability | 122,000,000.0 | $ 122,032,000 |  |  | $ 115,200,000 |
Difference between Revenue Guidance in Effect before and after Topic 606 |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  | $ 3,300,000
Variable consideration of accounting principle | 600,000 |  |  |  |  |
Fifth Anniversary |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Letters of credit | $ 3,800,000 |  |  |  |  |
Term for letter of credit (in years) | 5 years |  |  |  |  |
Non-US |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Net product sales | $ 190,300,000 | 171,000,000.0 | $ 145,200,000 |  |  |
United States |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |
Net product sales | $ 101,000,000.0 | $ 92,000,000.0 | $ 28,800,000 |  |  |

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