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Acquisitions - Narrative (Details) - USD ($) $ in Thousands |  |  |  | 4 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Oct. 25, 2019 | Aug. 23, 2018 | Apr. 20, 2017 | Dec. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Research and development |  |  |  |  | $ 257,452 | $ 171,984 | $ 117,456
Contingent consideration payable |  |  |  | $ 310,240 | $ 356,300 | 310,240 |
Issuance of common stock related to acquisition |  |  |  |  |  | 155,860 | 75,191
Useful life |  |  |  |  | 7 years |  |
BioElectron |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Payments for asset acquisitions | $ 10,000 |  |  |  |  |  |
Loan advance | 4,000 |  |  |  |  |  |
Escrow deposit disbursements related to property acquisition | 1,500 |  |  |  |  |  |
Research and development |  |  |  |  | $ 10,000 |  |
Acquisition costs | 500 |  |  |  |  |  |
Acquisition Costs, Cumulative |  |  |  |  | 10,500 |  |
Cash consideration | 10,000 |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  | 200,000 |  |
Intellectual Property | Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Payments for asset acquisitions |  |  | $ 75,000 |  |  |  |
Acquisition costs |  |  | $ (2,163) |  |  |  |
Issuance of common stock related to acquisition (in shares) |  |  | 6,683,598 |  |  |  |
Issuance of common stock related to acquisition |  |  | $ 75,190 |  |  |  |
Useful life |  |  | 7 years |  |  |  |
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Cash consideration |  |  | $ 75,000 |  |  |  |
Numerator for calculation of number of shares of equity interests issued to acquire entity |  |  | $ 65,000 |  |  |  |
Trading day period |  |  | 15 days |  |  |  |
Development milestone payment obligations |  |  | $ 50,000 |  |  |  |
Agilis |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Cash consideration |  | $ 49,221 |  |  |  |  |
Numerator for calculation of number of shares of equity interests issued to acquire entity |  | $ 150,000 |  |  |  |  |
Trading day period |  | 10 days |  |  |  |  |
Fair value of PTC common stock issued |  | $ 155,860 |  |  |  |  |
Development milestone payment obligations |  | 40,000 |  |  | 40,000 |  |
Estimated fair value of contingent consideration payable |  | 290,500 |  |  |  |  |
Estimated fair value of deferred consideration payable |  | 38,100 |  |  |  |  |
Total consideration |  | 533,681 |  |  |  |  |
Estimated fair value of contingent consideration payable |  |  |  |  |  | 1,700 |
Loss of acquire since acquisition date |  |  |  | $ 8,700 |  |  |
Net loss attributable to common stockholders |  |  |  |  |  | (138,083) | $ (93,333)
Agilis | Non-collaborative Arrangement Transactions |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Development milestone payment obligations |  | $ 40,000 |  |  | 40,000 |  |
Acquisition-related Costs | Agilis |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Net loss attributable to common stockholders |  |  |  |  |  | $ 1,700 |
Maximum | BioElectron |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Net sales milestones | $ 200,000 |  |  |  |  |  |
Maximum | Agilis |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Net sales milestones |  |  |  |  | $ 150,000 |  |
Percentage of annual net sales |  |  |  |  | 6.00% |  |
Development milestone payment obligations |  |  |  |  | $ 60,000 |  |
Priority review voucher amount |  |  |  |  | $ 535,000 |  |
Minimum | Agilis |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Percentage of annual net sales |  |  |  |  | 2.00% |  |
Common stock |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |
Issuance of common stock related to acquisition (in shares) |  |  |  |  |  | 3,500,907 | 6,683,598
Issuance of common stock related to acquisition |  |  |  |  |  | $ 3 | $ 7

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- Definition This element represents the amount of earnings or loss of the acquiree since the acquisition date included in the consolidated income statement for the reporting period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=79982066&loc=d3e1392-128463 + Details
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