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Fair value of financial instruments and investments - Narrative (Details) | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2019 USD ($) $ / shares | Dec. 31, 2018 USD ($) $ / shares | Dec. 31, 2017 USD ($) | Sep. 30, 2019 USD ($) | May 31, 2019 USD ($) $ / shares | Aug. 23, 2018 USD ($) | Apr. 30, 2018 $ / shares | Aug. 31, 2015 USD ($)
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Share price (in USD per share) | $ / shares |  |  |  |  |  |  | $ 27.04 |
Unrealized (gains) losses of MRI investment | $ 2,194,000 | $ 0 | $ 0 |  |  |  |  |
Investment In MRI | 6,200,000 |  |  |  |  |  |  |
Marketable securities | 398,535,000 | 58,088,000 |  |  |  |  |  |
Contingent consideration payable | 356,300,000 | 310,240,000 |  |  |  |  |  |
Deferred consideration payable- current | 40,000,000 | 19,400,000 |  |  |  |  |  |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Principal | 150,000,000 | 150,000,000 |  |  |  |  |  | $ 150,000,000.0
Interest rate |  |  |  |  |  |  |  | 3.00%
Debt instrument | 171,200,000 | 146,600,000 |  |  |  |  |  |
Convertible Senior Notes, 1.5%, Due September 15, 2026 | Convertible debt |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Principal | $ 287,500,000 |  |  | $ 287,500,000 |  |  |  |
Interest rate | 1.50% |  |  | 1.50% |  |  |  |
Debt instrument | $ 335,000,000.0 |  |  |  |  |  |  |
Stock Appreciation Rights (SARs) |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties | $ 3,186,000 | $ 3,814,000 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Minimum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | $ / shares | 6.76 | 6.76 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | $ / shares | 30.86 | 30.86 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Volatility | Minimum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | 0.2893 | 0.4653 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Volatility | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input |  | 0.5959 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Risk free interest rate | Minimum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | 0.0019 | 0.0244 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Risk free interest rate | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input |  | 0.0263 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Expected life | Minimum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | 0.01 | 0.01 |  |  |  |  |  |
Stock Appreciation Rights (SARs) | Expected life | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | 1.01 | 1.01 |  |  |  |  |  |
Common stock | Stock Appreciation Rights (SARs) | Fair value of common stock |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Measurement input | $ / shares | 48.03 | 34.32 |  |  |  |  |  |
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Marketable securities | $ 398,535,000 | $ 58,088,000 |  |  |  |  |  |
Deferred consideration payable | 40,000,000 | 37,700,000 |  |  |  |  |  |
Stock appreciation rights liability | 0 | 0 |  |  |  |  |  |
Contingent consideration payable |  | 0 |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties |  | 0 |  |  |  |  |  |
Agilis |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Development milestone payment obligations | 40,000,000.0 |  |  |  |  | $ 40,000,000.0 |  |
Deferred consideration payable |  |  |  |  |  | 38,100,000 |  |
Agilis | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Development milestone payment obligations | 60,000,000.0 |  |  |  |  |  |  |
Priority review voucher amount | 535,000,000.0 |  |  |  |  |  |  |
Agilis | Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Contingent consideration payable | 0 |  |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties | 0 |  |  |  |  |  |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Development milestone payment obligations | 40,000,000.0 |  |  |  |  | $ 40,000,000.0 |  |
Total | Fair Value, Measurements, Recurring |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Marketable securities | 398,535,000 | 58,088,000 |  |  |  |  |  |
Deferred consideration payable | 40,000,000 | 37,700,000 |  |  |  |  |  |
Stock appreciation rights liability | 3,186,000 | 3,814,000 |  |  |  |  |  |
Contingent consideration payable |  | 257,040,000 |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties |  | $ 53,200,000 |  |  |  |  |  |
Total | Agilis | Fair Value, Measurements, Recurring |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Contingent consideration payable | 290,500,000 |  |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties | 65,800,000 |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Purchase investment |  |  |  |  | $ 4,000,000.0 |  |  |
Share price (in USD per share) | $ / shares |  |  |  |  | $ 3.10 |  |  |
Unrealized (gains) losses of MRI investment | $ 2,200,000 |  |  |  |  |  |  |

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