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Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Revenue	$ 306,980	$ 264,734	$ 194,392
Operating expenses:
Cost of Goods and Services Sold	12,135	12,670	4,577
Amortization of acquired intangible asset	27,650	22,877	15,380
Research and development	257,452	171,984	117,456
Selling, general and administrative	202,541	153,548	121,271
Change in the fair value of deferred and contingent consideration	48,360	19,340	0
Total operating expenses	548,138	380,419	258,684
Loss from operations	(241,158)	(115,685)	(64,292)
Interest expense, net	(12,491)	(12,554)	(12,094)
Other income (expense), net	13,723	129	(1,279)
Loss before income tax expense	(239,926)	(128,110)	(77,665)
Income tax (expense) benefit	(11,650)	29	(1,335)
Net loss attributable to common stockholders	$ (251,576)	$ (128,081)	$ (79,000)
Weighted-average shares outstanding:
Basic and diluted (in shares)	58,863,185	46,576,313	39,183,073
Net loss per share—basic and diluted (in dollars per share)	$ (4.27)	$ (2.75)	$ (2.02)
Net product revenue
Revenues:
Revenue	$ 291,306	$ 263,005	$ 174,066
Collaboration and grant revenue
Revenues:
Revenue	$ 15,674	$ 1,729	$ 20,326

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