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Income taxes (Tables)

12 Months Ended

Dec. 31, 2019

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2019, 2018, and 2017:

		2019				2018				2017
Domestic		$	(231,915	)		$	(68,461	)		$	(54,588	)
Foreign		(8,011		)		(59,649		)		(23,077		)
Total		$	(239,926	)		$	(128,110	)		$	(77,665	)

Components of Income Tax Provision

The Income Tax Provision consisted of the following for the years ended December 31, 2019, 2018 and 2017:

		2019				2018				2017
Current:
U.S. Federal		$	—			$	—			$	—
U.S. State and Local		(61		)		(38		)		(6		)
Foreign		(2,041		)		(669		)		(1,131		)
Deferred:
U.S. Federal		—				—				(198		)
U.S. State and Local		(8,812		)		—				—
Foreign		(736		)		736				—
Total tax benefit (expense)		$	(11,650	)		$	29			$	(1,335	)

Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate

A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:

		December 31,
		2019			2018			2017
Federal income tax provision at statutory rate		21.00	%		21.00	%		34.00	%
State income tax provision, net of federal benefit		1.08			0.05			(1.01	)
Permanent differences		(6.17	)		(6.41	)		(8.48	)
Research and development		4.38			6.49			19.53
Change in valuation allowances		(35.49	)		2.20			29.10
Change in deferred tax assets		15.89			(14.22	)		(64.12	)
Foreign tax rate differential		(1.88	)		(9.10	)		(10.33	)
Benefit allocated from other comprehensive income		—			—			(0.26	)
Tax rate change		(3.67	)		—			—
Other		—			0.01			(0.15	)
Effective income tax rate		(4.86	)%		0.02	%		(1.72	)%

Schedule of significant components of the Company's deferred tax assets and liabilities

The significant components of the Company’s deferred tax assets and liabilities at December 31, 2019 and 2018 are as follows:

		2019				2018
Deferred tax assets:
Accrued expense		$	2,588			$	714
Amortization		78,291				5,148
Depreciation		991				1,601
Federal tax credits		99,421				89,070
State tax credits		6,489				5,473
Federal net operating losses		91,010				62,159
State net operating losses		1,360				165
Foreign net operating losses		1,056				736
Capitalized research and development costs		1,274				2,093
Share based compensation and other		16,425				21,411
Other comprehensive loss		1,512				—
Total gross deferred tax assets		300,417				188,570
Less valuation allowance		(267,131		)		(180,481		)
Total deferred tax assets, net of valuation allowance		$	33,286			$	8,089
Deferred tax liabilities:
Convertible debt		$	(33,286	)		$	(7,353	)
Indefinite lived intangible		(130,862		)		(122,032		)
Total gross deferred tax liabilities		(164,148		)		(129,385		)
Net deferred tax assets (liabilities)		$	(130,862	)		$	(121,296	)

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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