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Acquisitions - Narrative (Details) - USD ($) $ in Thousands				4 Months Ended	12 Months Ended
	Oct. 25, 2019	Aug. 23, 2018	Apr. 20, 2017	Dec. 31, 2018	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Finite-Lived Intangible Assets [Line Items]
Research and development					$ 257,452	$ 171,984	$ 117,456
Contingent consideration payable				$ 310,240	$ 356,300	310,240
Issuance of common stock related to acquisition						155,860	75,191
Useful life					7 years
BioElectron
Finite-Lived Intangible Assets [Line Items]
Payments for asset acquisitions	$ 10,000
Loan advance	4,000
Escrow deposit disbursements related to property acquisition	1,500
Research and development					$ 10,000
Acquisition costs	500
Acquisition Costs, Cumulative					10,500
Cash consideration	10,000
Development milestone payment obligations					200,000
Intellectual Property | Marathon Pharmaceuticals, LLC
Finite-Lived Intangible Assets [Line Items]
Payments for asset acquisitions			$ 75,000
Acquisition costs			$ (2,163)
Issuance of common stock related to acquisition (in shares)			6,683,598
Issuance of common stock related to acquisition			$ 75,190
Useful life			7 years
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Finite-Lived Intangible Assets [Line Items]
Cash consideration			$ 75,000
Numerator for calculation of number of shares of equity interests issued to acquire entity			$ 65,000
Trading day period			15 days
Development milestone payment obligations			$ 50,000
Agilis
Finite-Lived Intangible Assets [Line Items]
Cash consideration		$ 49,221
Numerator for calculation of number of shares of equity interests issued to acquire entity		$ 150,000
Trading day period		10 days
Fair value of PTC common stock issued		$ 155,860
Development milestone payment obligations		40,000			40,000
Estimated fair value of contingent consideration payable		290,500
Estimated fair value of deferred consideration payable		38,100
Total consideration		533,681
Estimated fair value of contingent consideration payable						1,700
Loss of acquire since acquisition date				$ 8,700
Net loss attributable to common stockholders						(138,083)	$ (93,333)
Agilis | Non-collaborative Arrangement Transactions
Finite-Lived Intangible Assets [Line Items]
Development milestone payment obligations		$ 40,000			40,000
Acquisition-related Costs | Agilis
Finite-Lived Intangible Assets [Line Items]
Net loss attributable to common stockholders						$ 1,700
Maximum | BioElectron
Finite-Lived Intangible Assets [Line Items]
Net sales milestones	$ 200,000
Maximum | Agilis
Finite-Lived Intangible Assets [Line Items]
Net sales milestones					$ 150,000
Percentage of annual net sales					6.00%
Development milestone payment obligations					$ 60,000
Priority review voucher amount					$ 535,000
Minimum | Agilis
Finite-Lived Intangible Assets [Line Items]
Percentage of annual net sales					2.00%
Common stock
Finite-Lived Intangible Assets [Line Items]
Issuance of common stock related to acquisition (in shares)						3,500,907	6,683,598
Issuance of common stock related to acquisition						$ 3	$ 7

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