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Fair value of financial instruments and investments - Narrative (Details)	12 Months Ended
	Dec. 31, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares	Dec. 31, 2017 USD ($)	Sep. 30, 2019 USD ($)	May 31, 2019 USD ($) $ / shares	Aug. 23, 2018 USD ($)	Apr. 30, 2018 $ / shares	Aug. 31, 2015 USD ($)
Financial assets and liabilities measured at fair value on recurring basis
Share price (in USD per share) | $ / shares							$ 27.04
Unrealized (gains) losses of MRI investment	$ 2,194,000	$ 0	$ 0
Investment In MRI	6,200,000
Marketable securities	398,535,000	58,088,000
Contingent consideration payable	356,300,000	310,240,000
Deferred consideration payable- current	40,000,000	19,400,000
3.00% Convertible senior notes due 2022 | Convertible debt
Financial assets and liabilities measured at fair value on recurring basis
Principal	150,000,000	150,000,000						$ 150,000,000.0
Interest rate								3.00%
Debt instrument	171,200,000	146,600,000
Convertible Senior Notes, 1.5%, Due September 15, 2026 | Convertible debt
Financial assets and liabilities measured at fair value on recurring basis
Principal	$ 287,500,000			$ 287,500,000
Interest rate	1.50%			1.50%
Debt instrument	$ 335,000,000.0
Stock Appreciation Rights (SARs)
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable- net sales milestones and royalties	$ 3,186,000	$ 3,814,000
Stock Appreciation Rights (SARs) | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input | $ / shares	6.76	6.76
Stock Appreciation Rights (SARs) | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input | $ / shares	30.86	30.86
Stock Appreciation Rights (SARs) | Volatility | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input	0.2893	0.4653
Stock Appreciation Rights (SARs) | Volatility | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input		0.5959
Stock Appreciation Rights (SARs) | Risk free interest rate | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input	0.0019	0.0244
Stock Appreciation Rights (SARs) | Risk free interest rate | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input		0.0263
Stock Appreciation Rights (SARs) | Expected life | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input	0.01	0.01
Stock Appreciation Rights (SARs) | Expected life | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Measurement input	1.01	1.01
Common stock | Stock Appreciation Rights (SARs) | Fair value of common stock
Financial assets and liabilities measured at fair value on recurring basis
Measurement input | $ / shares	48.03	34.32
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities	$ 398,535,000	$ 58,088,000
Deferred consideration payable	40,000,000	37,700,000
Stock appreciation rights liability	0	0
Contingent consideration payable		0
Contingent consideration payable- net sales milestones and royalties		0
Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	40,000,000.0					$ 40,000,000.0
Deferred consideration payable						38,100,000
Agilis | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	60,000,000.0
Priority review voucher amount	535,000,000.0
Agilis | Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	0
Contingent consideration payable- net sales milestones and royalties	0
Non-collaborative Arrangement Transactions | Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	40,000,000.0					$ 40,000,000.0
Total | Fair Value, Measurements, Recurring
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities	398,535,000	58,088,000
Deferred consideration payable	40,000,000	37,700,000
Stock appreciation rights liability	3,186,000	3,814,000
Contingent consideration payable		257,040,000
Contingent consideration payable- net sales milestones and royalties		$ 53,200,000
Total | Agilis | Fair Value, Measurements, Recurring
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	290,500,000
Contingent consideration payable- net sales milestones and royalties	65,800,000
Common stock
Financial assets and liabilities measured at fair value on recurring basis
Purchase investment					$ 4,000,000.0
Share price (in USD per share) | $ / shares					$ 3.10
Unrealized (gains) losses of MRI investment	$ 2,200,000

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