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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
Accumulated other comprehensive (loss) income
Accumulated deficit
Balance (in shares) at Dec. 31, 2016   34,169,410      
Balance at the beginning of the period at Dec. 31, 2016 $ 119,583 $ 34 $ 856,142 $ (1,485) $ (735,108)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to acquisition (in shares)   6,683,598      
Issuance of common stock related to acquisition 75,191 $ 7 75,184    
Exercise of options (in shares)   202,085      
Exercise of options 2,182   2,182    
Restricted stock vesting and issuance (in shares)   287,531      
Restricted stock vesting and issuance 1 $ 1      
Issuance of common stock in connection with an employee stock purchase plan (in shares)   269,771      
Issuance of common stock in connection with an employee stock purchase plan 2,467   2,467    
Share-based compensation expense 30,559   30,559    
Net loss (79,000)       (79,000)
Comprehensive loss 5,454     5,454  
Balance (in shares) at Dec. 31, 2017   41,612,395      
Balance at the end of the period at Dec. 31, 2017 156,437 $ 42 966,534 3,969 (814,108)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offerings (in shares)   4,600,000      
Issuance of common stock related to equity offerings 117,916 $ 5 117,911    
Issuance of common stock related to acquisition (in shares)   3,500,907      
Issuance of common stock related to acquisition 155,860 $ 3 155,857    
Exercise of options (in shares)   633,973      
Exercise of options 10,868 $ 1 10,867    
Restricted stock vesting and issuance (in shares)   119,691      
Restricted stock vesting and issuance 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   139,181      
Issuance of common stock in connection with an employee stock purchase plan 2,787   2,787    
Share-based compensation expense 33,252   33,252    
Receivable from Investor 929   929    
Net loss (128,081)       (128,081)
Comprehensive loss (2,507)     (2,507)  
Balance (in shares) at Dec. 31, 2018   50,606,147      
Balance at the end of the period at Dec. 31, 2018 350,727 $ 51 1,288,137 1,462 (938,923)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offerings (in shares)   10,102,899      
Issuance of common stock related to equity offerings 323,756 $ 10 323,746    
Equity component of convertible notes, net 119,482   119,482    
Exercise of options (in shares)   949,887      
Exercise of options 18,276 $ 1 18,275    
Restricted stock vesting and issuance 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   107,145      
Issuance of common stock in connection with an employee stock purchase plan 3,577   3,577    
Share-based compensation expense 42,134   42,134    
Net loss (251,576)       (251,576)
Comprehensive loss (12,046)     (12,046)  
Balance (in shares) at Dec. 31, 2019   61,935,870      
Balance at the end of the period at Dec. 31, 2019 $ 594,330 $ 62 $ 1,795,351 $ (10,584) $ (1,190,499)