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Stock award plan - Share-based Compensation (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Share-based compensation expense recorded in the statement of operations      
Share-based compensation expense $ 42,134 $ 33,252 $ 30,559
Research and development      
Share-based compensation expense recorded in the statement of operations      
Share-based compensation expense 20,836 16,096 15,456
Selling, general and administrative      
Share-based compensation expense recorded in the statement of operations      
Share-based compensation expense $ 21,298 $ 17,156 $ 15,103