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Revenue recognition - Narrative (Details) $ in Millions	1 Months Ended						12 Months Ended
	Nov. 30, 2019 USD ($)	Oct. 31, 2017 USD ($)	Nov. 30, 2014 USD ($)	Jan. 31, 2014 USD ($)	Aug. 31, 2013 USD ($)	Nov. 30, 2011 USD ($) compound	Dec. 31, 2019 USD ($) segment Number_Distributor	Dec. 31, 2018 USD ($) deliverable	Dec. 31, 2017 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of operating segments | segment							1
Number of distributors | Number_Distributor							3
Percentage of net product sales							10.00%
Contract with customer, liability							$ 11.7	$ 12.9
Performance obligations satisfied in current period							3.9	0.0
United States
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product sales							101.0	92.0	$ 28.8
Non-US
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product sales							190.3	171.0	145.2
Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Performance obligations satisfied in current period	$ 15.0	$ 20.0	$ 10.0	$ 7.5	$ 10.0
Additions						$ 30.0
Revenue, remaining performance obligation, amount						$ 30.0
Revenue, remaining performance obligation, expected timing of satisfaction, period						2 years
Revenue							15.2	$ 0.2	$ 20.3
Collaborative Arrangement | Roche And Sma Foundation
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaborative arrangements number of compounds in preclinical development | compound						3
Collaborative arrangements number of significant deliverables | deliverable								2
Research And Development Event Milestones | Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, remaining milestone, potential achievements							72.5
Revenue recognition, milestone, potential achievements							135.0
Potential net sales milestones | Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements							$ 325.0

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