Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382

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Operating Loss Carryforwards, Available

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Represents the operating loss carryforwards for immediate use.

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Represents the operating loss carryforwards in next twelve months.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards that are not subject to expiration dates.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards that are subject to expiration dates.

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No definition available.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible general business tax credit carryforwards.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Amount recognized for uncertainty in income taxes classified as current.

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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.

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Income taxes - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
Income taxes - Narrative (Details) - USD ($) $ in Thousands	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Operating loss carryforwards
Valuation allowance	$ 267,131	$ 180,481
Valuation allowance, deferred tax asset, increase (decrease)	86,700	$ 2,800
Deferred Tax Assets, Operating Loss Carryforwards	231,500
Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382	231,500
Orphan drug credit carryover	85,200
Operating loss carryforwards, not subject to expiration	169,200
Operating loss carryforwards, subject to expiration	62,300
Operating loss carryforwards for immediate use	333,200
Operating loss carryforwards in next twelve months	$ 5,700
Federal income tax provision at statutory rate	21.00%	21.00%	34.00%
Uncertain tax position	$ 0
First five years from ownership change
Operating loss carryforwards
Net operating loss carryforwards	16,700
After five years
Operating loss carryforwards
Net operating loss carryforwards	5,700
Federal
Operating loss carryforwards
Net operating loss carryforwards	433,300
Research and development credit carryforwards	14,200
Operating Loss Carryforwards, Available	495,700
State
Operating loss carryforwards
Net operating loss carryforwards	224,400
Research and development credit carryforwards	6,200
Foreign Tax Authority
Operating loss carryforwards
Net operating loss carryforwards	$ 8,400