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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Disaggregation of Revenue [Line Items]
Revenue									$ 306,980	$ 264,734	$ 194,392
Operating expenses	$ 169,243	$ 131,891	$ 124,280	$ 122,723	$ 131,476	$ 101,821	$ 74,317	$ 72,805	548,138	380,419	258,684
Loss from operations	(72,784)	(60,475)	(38,758)	(69,140)	(45,138)	(48,230)	(5,574)	(16,743)	(241,158)	(115,685)	(64,292)
Net loss attributable to common stockholders	$ (77,677)	$ (59,997)	$ (41,789)	$ (72,113)	$ (48,330)	$ (50,969)	$ (9,520)	$ (19,263)	$ (251,576)	$ (128,081)	$ (79,000)
Basic and diluted net loss per common share (in dollars per share)	$ (1.37)	$ (1.06)	$ (0.75)	$ (1.29)	$ 0.96	$ (1.06)	$ (0.21)	$ (0.46)	$ (4.27)	$ (2.75)	$ (2.02)
Net product revenue
Disaggregation of Revenue [Line Items]
Revenue	$ 81,407	$ 71,369	$ 85,476	$ 53,054	$ 85,833	$ 53,021	$ 68,170	$ 55,981	$ 291,306	$ 263,005	$ 174,066
Collaboration and grant revenue
Disaggregation of Revenue [Line Items]
Revenue	$ 15,052	$ 47	$ 46	$ 529	$ 505	$ 570	$ 573	$ 81	$ 15,674	$ 1,729	$ 20,326

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