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Fair value of financial instruments and marketable securities - Narrative (Details) | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |  |  |
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Jan. 31, 2020 USD ($) | Jun. 30, 2020 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) | Jun. 30, 2020 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) | Jun. 29, 2020 USD ($) | Apr. 29, 2020 USD ($) | Dec. 31, 2019 USD ($) | May 31, 2019 USD ($) $ / shares | Dec. 31, 2018 USD ($) | Aug. 31, 2015 USD ($) $ / shares
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Marketable Securities, Realized Gain (Loss) |  | $ 200,000 |  | $ 200,000 |  |  |  |  |  |  |
Deferred consideration payable |  | 2,384,000 |  | 2,384,000 |  |  |  | $ 40,000,000 |  |  |
Unrealized gain (loss) on equity investment |  |  |  | (1,600,000) | $ 129,000 |  |  |  |  |  |
Investment In MRI |  | $ 4,600,000 |  | 4,600,000 |  |  |  |  |  |  |
Purchase of convertible debt investment | $ 10,000,000.0 |  |  | $ 10,000,000 | 0 |  |  |  |  |  |
Conversion price per share (in dollars per share) | $ / shares |  | $ 6.00 |  | $ 6.00 |  |  |  |  |  |  |
Debt instrument, convertible, period |  |  |  | 5 years |  |  |  |  |  |  |
Unrealized loss |  |  |  | $ 700,000 |  |  |  |  |  |  |
Marketable securities |  | $ 340,430,000 |  | 340,430,000 |  |  |  | 398,535,000 |  |  |
Non-cash stock consideration, acquisition |  |  |  | 42,869,000 | 0 |  |  |  |  |  |
Operating Expenses |  | 262,512,000 | $ 124,280,000 | 423,762,000 | 247,003,000 |  |  |  |  |  |
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |  | (7,680,000) | (5,300,000) | $ (8,580,000) | (26,460,000) |  |  |  |  |  |
Debt Securities, Available-for-sale, Unrealized Gain |  | $ 2,100,000 |  |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock related to rights exchange (in shares) | shares |  | 2,821,176 |  | 2,821,176 |  |  |  |  |  |  |
Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | $ 136,100,000 | 277,400,000 | $ 136,100,000 | 277,400,000 |  |  | 290,500,000 |  | $ 257,040,000 |
SARs |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | 0 | $ 1,960,000 | 0 | $ 1,960,000 |  |  | 3,186,000 |  | $ 3,814,000 |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Principal |  | 150,000,000 |  | 150,000,000 |  |  |  | 150,000,000 |  |  | $ 150,000,000.0
Interest rate ( as a percent ) |  |  |  |  |  |  |  |  |  |  | 3.00%
Fair value of convertible notes |  | 175,200,000 |  | 175,200,000 |  |  |  | 171,200,000 |  |  |
Conversion price per share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 56.34
1.50% Convertible senior notes due 2026 | Convertible debt |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Principal |  | $ 287,500,000 |  | $ 287,500,000 |  |  |  | $ 287,500,000 |  |  |
Interest rate ( as a percent ) |  | 1.50% |  | 1.50% |  |  |  | 1.50% |  |  |
Fair value of convertible notes |  | $ 343,800,000 |  | $ 343,800,000 |  |  |  | $ 335,000,000.0 |  |  |
Conversion price per share (in dollars per share) | $ / shares |  | $ 52.52 |  | $ 52.52 |  |  |  |  |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 40,000,000.0 |  | $ 40,000,000.0 |  |  | $ 40,000,000.0 |  |  |  |
Net sales amount |  |  |  |  |  |  | $ 150,000,000.0 |  |  |  |
Deferred consideration payable |  | 2,400,000 |  | 2,400,000 |  |  |  |  |  |  |
Non-cash stock consideration, acquisition |  | 36,900,000 |  |  |  |  |  |  |  |  |
Milestone Payment Obligations |  |  |  |  |  | $ 174,000,000.0 |  |  |  |  |
Gain Of Settlement, Development Milestones |  | 700,000 |  |  |  |  |  |  |  |  |
Loss Of Settlement, Regulatory Milestones |  | 11,300,000 |  |  |  |  |  |  |  |  |
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |  | 1,000,000.0 |  |  |  |  |  |  |  |  |
Contingent Consideration, Transaction Fees |  | $ 2,000,000.0 |  | $ 2,000,000.0 |  |  |  |  |  |  |
Agilis | Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock related to rights exchange (in shares) | shares |  |  |  | 2,821,176 |  |  |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Product sales |  | 2.00% |  | 2.00% |  |  | 2.00% |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  |  | 37,600,000 |  |  |  |  |
Agilis | Maximum |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Product sales |  | 6.00% |  | 6.00% |  |  | 6.00% |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 60,000,000.0 |  | $ 60,000,000.0 |  | $ 40,000,000.0 |  |  |  |  |
Priority review voucher amount |  |  |  | 535,000,000.0 |  |  |  |  |  |  |
Net sales amount |  | 150,000,000.0 |  | 150,000,000.0 |  |  |  |  |  |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | 40,000,000.0 |  | 40,000,000.0 |  |  |  |  |  |  |
Recurring basis | Total |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Estimated fair value of deferred consideration payable |  | 2,384,000 |  | 2,384,000 |  |  |  | 40,000,000 |  |  |
Liability value |  | 89,600,000 |  | 89,600,000 |  |  |  | 65,800,000 |  |  |
Marketable securities |  |  |  |  |  |  |  | $ 398,535,000 |  |  |
Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Shares owned |  |  |  |  |  |  |  |  | $ 4,000,000.0 |  |
Fair value of shares (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 3.10 |  |
Unrealized gain (loss) on equity investment |  | 100,000 |  | 1,600,000 |  |  |  |  |  |  |
Deferred consideration payable | Recurring basis | Total |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Marketable securities |  | $ 9,251,000 |  | $ 9,251,000 |  |  |  |  |  |  |
Development and Regulatory Milestone | Probability of Success [Member] | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.25 |  | 0.25 |  |  |  | 0.25 |  |  |
Development and Regulatory Milestone | Probability of Success [Member] | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.94 |  | 0.94 |  |  |  | 0.94 |  |  |
Development and Regulatory Milestone | Probability of Success [Member] | Weighted Average [Member] | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.43 |  | 0.43 |  |  |  |  |  |  |
Development and Regulatory Milestone | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | $ 136,100,000 |  | $ 136,100,000 |  |  |  | $ 290,500,000 |  |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  |  |  |  |  |  |  | 0.022 |  |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  |  |  |  |  |  |  | 0.047 |  |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Weighted Average [Member] | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.054 |  | 0.054 |  |  |  |  |  |  |
Liability, Net Sales Milestones and Royalties [Member] | Probability of Success [Member] | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.25 |  | 0.25 |  |  |  | 0.25 |  |  |
Liability, Net Sales Milestones and Royalties [Member] | Probability of Success [Member] | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.94 |  | 0.94 |  |  |  | 0.89 |  |  |
Liability, Net Sales Milestones and Royalties [Member] | Probability of Success [Member] | Weighted Average [Member] | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.50 |  | 0.50 |  |  |  |  |  |  |
Liability, Net Sales Milestones and Royalties [Member] | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | $ 89,600,000 |  | $ 89,600,000 |  |  |  | $ 65,800,000 |  |  |
Liability, Net Sales Milestones and Royalties [Member] | Agilis | Measurement Input, Discount Rate | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Alternative Investment, Measurement Input |  | 0.120 |  | 0.120 |  |  |  | 0.145 |  |  |

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