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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common stock | Additional paid-in capital | AOCI Attributable to Parent | Accumulated deficit
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2018 |  | 50,606,147 |  |  |
Balance at the beginning of the period at Dec. 31, 2018 | $ 350,727 | $ 51 | $ 1,288,137 | $ 1,462 | $ (938,923)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 7,563,725 |  |  |
Issuance of common stock related to equity offering | 224,545 | $ 7 | 224,538 |  |
Issuance of common stock related to rights exchange | 0 |  |  |  |
Exercised (in shares) |  | 311,002 |  |  |
Exercise of options | 4,129 | $ 0 | 4,129 |  |
Restricted stock vesting and issuance, net (in shares) |  | 171,592 |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 54,719 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,564 | $ 0 | 1,564 |  |
Share-based compensation expense | 20,184 |  | 20,184 |  |
Receivable from investor | 978 |  | 978 |  |
Net loss | (113,902) |  |  |  | (113,902)
Comprehensive income | 460 |  |  | 460 |
Balance (in shares) at Jun. 30, 2019 |  | 58,707,185 |  |  |
Balance at the end of the period at Jun. 30, 2019 | 488,685 | $ 58 | 1,539,530 | 1,922 | (1,052,825)
Balance (in shares) at Mar. 31, 2019 |  | 58,418,790 |  |  |
Balance at the beginning of the period at Mar. 31, 2019 | 512,942 | $ 58 | 1,523,115 | 805 | (1,011,036)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 0 |  |  |
Issuance of common stock related to equity offering | 106 | $ 0 | 106 |  |
Exercised (in shares) |  | 230,176 |  |  |
Exercise of options | 2,847 |  | 2,847 |  |
Restricted stock vesting and issuance, net (in shares) |  | 3,500 |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 54,719 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,564 | $ 0 | 1,564 |  |
Share-based compensation expense | 10,920 |  | 10,920 |  |
Receivable from investor | 978 |  | 978 |  |
Net loss | (41,789) |  |  |  | (41,789)
Comprehensive income | 1,117 |  |  | 1,117 |
Balance (in shares) at Jun. 30, 2019 |  | 58,707,185 |  |  |
Balance at the end of the period at Jun. 30, 2019 | 488,685 | $ 58 | 1,539,530 | 1,922 | (1,052,825)
Balance (in shares) at Dec. 31, 2019 |  | 61,935,870 |  |  |
Balance at the beginning of the period at Dec. 31, 2019 | 594,330 | $ 62 | 1,795,351 | (10,584) | (1,190,499)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 368,514 |  |  |
Issuance of common stock related to equity offering | 18,950 | $ 0 | 18,950 |  |
Payments for asset acquisitions, shares (in shares) |  | 845,364 |  |  |
Payments for asset acquisitions, share, value | 42,869 | $ 1 | 42,868 |  |
Issuance of common stock related to rights exchange (in shares) |  | 2,821,176 |  |  |
Issuance of common stock related to rights exchange | 150,528 | $ 3 | 150,525 |  |
Exercised (in shares) |  | 1,034,288 |  |  |
Exercise of options | 25,045 | $ 1 | 25,044 |  |
Restricted stock vesting and issuance, net (in shares) |  | 176,776 |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 58,691 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 2,406 | $ 0 | 2,406 |  |
Share-based compensation expense | 32,130 |  | 32,130 |  |
Other | (218) |  |  |  |
Net loss | (294,114) |  |  |  | (294,114)
Comprehensive income | 568 |  |  | 568 |
Balance (in shares) at Jun. 30, 2020 |  | 67,240,679 |  |  |
Balance at the end of the period at Jun. 30, 2020 | 572,494 | $ 67 | 2,067,274 | (10,016) | (1,484,831)
Balance (in shares) at Mar. 31, 2020 |  | 62,758,520 |  |  |
Balance at the beginning of the period at Mar. 31, 2020 | 528,734 | $ 62 | 1,834,061 | (1,985) | (1,303,404)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 106,309 |  |  |
Issuance of common stock related to equity offering | 5,447 | $ 0 | 5,447 |  |
Payments for asset acquisitions, shares (in shares) |  | 845,364 |  |  |
Payments for asset acquisitions, share, value | 42,869 | $ 1 | 42,868 |  |
Issuance of common stock related to rights exchange (in shares) |  | 2,821,176 |  |  |
Issuance of common stock related to rights exchange | 150,528 | $ 3 | 150,525 |  |
Exercised (in shares) |  | 654,604 |  |  |
Exercise of options | 15,058 | $ 1 | 15,057 |  |
Restricted stock vesting and issuance, net (in shares) |  | (3,985) |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 58,691 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 2,406 | $ 0 | 2,406 |  |
Share-based compensation expense | 16,910 |  | 16,910 |  |
Net loss | (181,427) |  |  |  |
Comprehensive income | (8,031) |  |  | (8,031) |
Balance (in shares) at Jun. 30, 2020 |  | 67,240,679 |  |  |
Balance at the end of the period at Jun. 30, 2020 | $ 572,494 | $ 67 | $ 2,067,274 | $ (10,016) | $ (1,484,831)

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