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The Company - Narrative (Details) - USD ($) $ in Thousands |  |  | 6 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Apr. 29, 2020 | Aug. 23, 2018 | Jun. 30, 2020 | Jun. 29, 2020 | Dec. 31, 2019 | Apr. 20, 2017 | Aug. 31, 2015
Long-term debt |  |  |  |  |  |  |
Retained earnings (accumulated deficit) |  |  | $ (1,484,831) |  | $ (1,190,499) |  |
Rights Exchange Agreement [Member] |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Shares to issue under Rights Exchange Agreement | 2,821,176 |  |  |  |  |  |
Cash consideration payment under Rights Exchange Agreement | $ 36,900 |  |  |  |  |  |
Convertible debt | 1.50% Convertible senior notes due 2026 |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Interest rate ( as a percent ) |  |  | 1.50% |  | 1.50% |  |
Convertible debt | 3.00% Convertible senior notes due 2022 |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Interest rate ( as a percent ) |  |  |  |  |  |  | 3.00%
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  |  | $ 50,000 |
Agilis |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Cash consideration |  | $ 49,200 |  |  |  |  |
Equity Interest Issued, number of shares (in shares) |  | 3,500,907 |  |  |  |  |
Numerator for calculation of number of shares of equity interests issued to acquire entity |  | $ 150,000 |  |  |  |  |
Trading day period |  | 10 days |  |  |  |  |
Development milestone payments which the entity is obligated to pay | 40,000 |  | $ 40,000 |  |  |  |
Development Milestone Payment Obligations, Net of Cancellation and Forfeiture |  |  | $ 22,400 |  |  |  |
Net sales amount | $ 150,000 |  |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  | $ 37,600 |  |  |
Product sales | 2.00% |  | 2.00% |  |  |  |
Agilis | Maximum |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  | $ 60,000 | $ 40,000 |  |  |
Priority review voucher amount |  |  | 535,000 |  |  |  |
Net sales amount |  |  | $ 150,000 |  |  |  |
Product sales | 6.00% |  | 6.00% |  |  |  |
Agilis | Rights Exchange Agreement [Member] |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Priority review voucher amount | $ 174,000 |  |  |  |  |  |
Development Milestone Payment Obligations, Net of Cancellation and Forfeiture | 22,400 |  |  |  |  |  |
Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount, Net of Cancellation and Forfeiture | $ 361,000 |  |  |  |  |  |
Agilis | Rights Exchange Agreement [Member] | Maximum |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount, Net of Cancellation and Forfeiture |  |  | $ 361,000 |  |  |  |
Agilis | Non-collaborative Arrangement Transactions |  |  |  |  |  |  |
Long-term debt |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  | $ 40,000 |  |  |  |

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