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Stock award plan - (Tables)

6 Months Ended

Jun. 30, 2020

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

A summary of stock option activity is as follows:

						Number of options						Weighted- average exercise price						Weighted- average remaining contractual term						Aggregate intrinsic value (in thousands)
Outstanding at December 31, 2019						11,043,939						$	31.67
Granted						2,515,200						$	50.98
Exercised						(1,034,288)						$	24.21
Forfeited/Cancelled						(570,167)						$	42.27
Outstanding at June 30, 2020						11,954,684						$	35.84					7.48 years						$	183,488
Vested or Expected to vest at June 30, 2020						5,690,848						$	39.16					8.86 years						$	66,986
Exercisable at June 30, 2020						5,512,252						$	31.61					5.85 years						$	110,222

Schedule of assumptions used to estimate fair values of grants made on the date of grant

The fair value of grants made in the six months ended June 30, 2020 was contemporaneously estimated on the date of grant using the following assumptions:

						Six months ended June 30, 2020
Risk-free interest rate						0.40% - 1.45%
Expected volatility						87.50% - 89.31%
Expected term						5.75 years

Summary of information on the Company's restricted stock

The following table summarizes information on the Company’s restricted stock awards and units:

						Restricted Stock Awards and Units
						Number of Shares						Weighted Average Grant Date Fair Value
January 1, 2020						642,419						$	24.50
Granted						589,070						$	49.67
Vested						(229,076)						$	23.53
Forfeited						(65,491)						$	36.11
Unvested at June 30, 2020						936,922						$	39.97

Schedule of share-based compensation expense recorded in the statement of operations

The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:

						Three Months Ended June 30,																		Six Months Ended June 30,
						2020						2019						2020						2019
Research and development						$	8,562					$	5,516					$	16,741					$	10,203
Selling, general and administrative						8,348						5,404						15,389						9,981
Total						$	16,910					$	10,920					$	32,130					$	20,184

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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