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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Jan. 31, 2020	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Stock option plan
Share-based compensation expense		$ 16,910	$ 10,920	$ 32,130	$ 20,184
Research and development
Stock option plan
Share-based compensation expense		8,562	5,516	16,741	10,203
Selling, general and administrative
Stock option plan
Share-based compensation expense		$ 8,348	$ 5,404	$ 15,389	$ 9,981
Common stock
Stock option plan
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		914,406		914,406
Common stock | 2020 inducement stock incentive plan [Member]
Stock option plan
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number	1,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		442,880		442,880

X

- Definition

Represents the number of shares to be added annually on the first day of each fiscal year in the number of shares authorized.

+ References

No definition available.

+ Details

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5047-113901

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

+ References

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-Topic 718
-SubTopic 10
-Section 50
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