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Commitments and contingencies - Narrative (Details) - USD ($)
$ in Millions
 6 Months Ended
Jun. 29, 2020
Apr. 29, 2020
Jun. 30, 2020
May 29, 2020
Dec. 31, 2019
Sep. 30, 2019
Apr. 20, 2017
Sep. 30, 2016
Akcea                
Other Commitments [Abstract]                
Upfront licensing fee     $ 12.0          
Akcea | Maximum                
Other Commitments [Abstract]                
Milestone payments         $ 4.0      
Censa [Member]                
Other Commitments [Abstract]                
Asset acquisition, milestone, amount       $ 217.5        
Asset acquisition, development and regulatory milestones       109.0        
Asset acquisition, net sales milestone       160.0        
Asset acquisition, initial milestone       30.0        
Censa [Member] | Maximum                
Other Commitments [Abstract]                
Asset acquisition, milestone, amount       $ 217.5        
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay             $ 50.0  
Non-collaborative Arrangement Transactions | Akcea                
Other Commitments [Abstract]                
Milestone payments     4.0     $ 6.0    
Agilis                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay   $ 40.0 40.0          
Net sales amount   150.0            
Development Milestone Payment Obligations, Net of Cancellation and Forfeiture     22.4          
Agilis | Rights Exchange Agreement [Member]                
Other Commitments [Abstract]                
Priority review voucher amount   174.0            
Contingent Liability cancellation and forfeiture, Milestone, Potential Achievements, Priority Review Voucher Amount     174.0          
Development Milestone Payment Obligations, Cancellation and Forfeiture   37.6 37.6          
Development Milestone Payment Obligations, Net of Cancellation and Forfeiture   22.4            
Contingent Liability, Cancellation and Forfeiture $ 211.6 211.6            
Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount, Net of Cancellation and Forfeiture   $ 361.0            
Agilis | Maximum                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay 40.0   60.0          
Priority review voucher amount     535.0          
Net sales amount     $ 150.0          
Product sales   6.00% 6.00%          
Agilis | Maximum | Rights Exchange Agreement [Member]                
Other Commitments [Abstract]                
Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount, Net of Cancellation and Forfeiture     $ 361.0          
Agilis | Minimum                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay $ 37.6              
Product sales   2.00% 2.00%          
Agilis | Non-collaborative Arrangement Transactions                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay     $ 40.0          
BioElectron | Maximum                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay     200.0          
Product | Wellcome trust                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay               $ 0.8
Product | Wellcome trust | Maximum                
Other Commitments [Abstract]                
Development milestone payments which the entity is obligated to pay     $ 22.4