Milestone payment which the entity is obliged to pay upon regulatory approval

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Upfront Licensing Fee

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- Definition

The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method.

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- Definition

The amount of identifiable intangible assets recognized as of the acquisition date.

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- Definition

Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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No definition available.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Remaining amortization period of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.

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Amount of increase in assets, excluding financial assets and goodwill, lacking physical substance with an indefinite life, from an acquisition.

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No definition available.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2020	Mar. 31, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2019	Sep. 30, 2019	Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items]
Useful life		7 years
Amortization of acquired intangible assets	$ 8,731		$ 6,575	$ 16,679	$ 12,652
Total allocation of IPR&D assets				576,500
Goodwill	82,341			82,341		$ 82,341
Research and development	176,525		59,979	$ 266,632	112,544
Weighted Average [Member]
Finite-Lived Intangible Assets [Line Items]
Remaining amortization period				4 years
Akcea
Finite-Lived Intangible Assets [Line Items]
Upfront licensing fee				$ 12,000
Non-collaborative Arrangement Transactions \| Akcea
Finite-Lived Intangible Assets [Line Items]
Milestone payments	4,000			$ 4,000			$ 6,000
Useful life				10 years
Emflaza asset acquisition
Finite-Lived Intangible Assets [Line Items]
Finite-Lived intangibles								$ 148,400
Milestone payments	$ 12,200		$ 8,300	$ 12,200	$ 8,300