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Fair value of financial instruments and marketable securities - Narrative (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 9 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 31, 2020 | Sep. 30, 2020 | Sep. 30, 2019 | Jun. 30, 2020 | Sep. 30, 2020 | Sep. 30, 2019 | Jun. 29, 2020 | Apr. 29, 2020 | Dec. 31, 2019 | May 31, 2019 | Aug. 31, 2015
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Write downs of available for sale debt securities |  | $ 0 |  |  | $ 0 |  |  |  |  |  |
Realized gain (loss) from sale of marketable securities |  | 300,000 |  |  | 500,000 |  |  |  |  |  |
Increase in allowance for credit losses |  | 0 |  |  | 0 |  |  |  |  |  |
Deferred consideration payable |  | 0 |  |  | 0 |  |  |  | $ 40,000,000 |  |
Unrealized gain (loss) on equity investment |  |  |  |  | 852,000 | $ 2,529,000 |  |  |  |  |
Investment In MRI |  | $ 7,000,000.0 |  |  | 7,000,000.0 |  |  |  |  |  |
Purchase of convertible debt investment | $ 10,000,000.0 |  |  |  | $ 10,000,000 | 0 |  |  |  |  |
Conversion price per share (in dollars per share) |  | $ 6.00 |  |  | $ 6.00 |  |  |  |  |  |
Debt instrument, convertible, period |  |  |  |  | 5 years |  |  |  |  |  |
Marketable securities |  | $ 707,049,000 |  |  | $ 707,049,000 |  |  |  | 398,535,000 |  |
Transfers of assets measured between Level 1, Level 2, and Level 3 |  | 0 |  |  | 0 |  |  |  | 0 |  |
Non-cash stock consideration, acquisition |  |  |  |  | 42,869,000 | 0 |  |  |  |  |
Operating Expenses |  | 173,535,000 | $ 131,891,000 |  | 597,296,000 | 378,895,000 |  |  |  |  |
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |  | (8,400,000) | $ (9,500,000) |  | (16,980,000) | $ (35,960,000) |  |  |  |  |
Debt Securities, Available-for-sale, Unrealized Gain |  | 1,400,000 |  |  | $ 600,000 |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock related to rights exchange (in shares) |  |  |  |  | 2,821,176 |  |  |  |  |  |
SARs |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | 0 |  |  | $ 0 |  |  |  |  |  |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Principal |  | 150,000,000 |  |  | 150,000,000 |  |  |  | 150,000,000 |  | $ 150,000,000.0
Interest rate ( as a percent ) |  |  |  |  |  |  |  |  |  |  | 3.00%
Fair value of convertible notes |  | 171,300,000 |  |  | 171,300,000 |  |  |  | 171,200,000 |  |
Conversion price per share (in dollars per share) |  |  |  |  |  |  |  |  |  |  | $ 56.34
1.50% Convertible senior notes due 2026 | Convertible debt |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Principal |  | $ 287,500,000 |  |  | $ 287,500,000 |  |  |  | $ 287,500,000 |  |
Interest rate ( as a percent ) |  | 1.50% |  |  | 1.50% |  |  |  | 1.50% |  |
Fair value of convertible notes |  | $ 329,200,000 |  |  | $ 329,200,000 |  |  |  | $ 335,000,000.0 |  |
Conversion price per share (in dollars per share) |  | $ 52.52 |  |  | $ 52.52 |  |  |  |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 40,000,000.0 |  |  | $ 40,000,000.0 |  |  | $ 40,000,000.0 |  |  |
Net sales amount |  |  |  |  |  |  |  | $ 150,000,000.0 |  |  |
Deferred consideration payable |  | 0 |  |  | 0 |  |  |  |  |  |
Non-cash stock consideration, acquisition |  | 36,900,000 |  |  |  |  |  |  |  |  |
Milestone Payment Obligations |  |  |  |  |  |  | $ 174,000,000.0 |  |  |  |
Gain Of Settlement, Development Milestones |  | 700,000 |  |  |  |  |  |  |  |  |
Loss Of Settlement, Regulatory Milestones |  | 11,300,000 |  |  |  |  |  |  |  |  |
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |  | 1,000,000.0 |  |  |  |  |  |  |  |  |
Contingent Consideration, Transaction Fees |  | $ 2,000,000.0 |  |  | $ 2,000,000.0 |  |  |  |  |  |
Agilis | Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock related to rights exchange (in shares) |  |  |  | 2,821,176 |  |  |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Product sales |  | 2.00% |  |  | 2.00% |  |  | 2.00% |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  |  |  | 37,600,000 | $ 37,600,000 |  |  |
Agilis | Maximum |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Product sales |  | 6.00% |  |  | 6.00% |  |  | 6.00% |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 60,000,000.0 |  |  | $ 60,000,000.0 |  | $ 40,000,000.0 |  |  |  |
Priority review voucher amount |  |  |  |  | 535,000,000.0 |  |  |  |  |  |
Net sales amount |  | 150,000,000.0 |  |  | 150,000,000.0 |  |  |  |  |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | 40,000,000.0 |  |  | 40,000,000.0 |  |  |  |  |  |
Recurring basis | Total |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Estimated fair value of deferred consideration payable |  | 2,400,000 |  |  | 2,400,000 |  |  |  | 40,000,000 |  |
Liability value |  | 95,900,000 |  |  | 95,900,000 |  |  |  | 65,800,000 |  |
Common stock |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Shares owned |  |  |  |  |  |  |  |  |  | $ 4,000,000.0 |
Fair value of shares (in dollars per share) |  |  |  |  |  |  |  |  |  | $ 3.10 |
Unrealized gain (loss) on equity investment |  | 2,500,000 |  |  | 900,000 |  |  |  |  |  |
Deferred consideration payable | Recurring basis | Total |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Marketable securities |  | $ 10,633,000 |  |  | $ 10,633,000 |  |  |  |  |  |
Development and Regulatory Milestone | Probability of Success | Weighted Average | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 42 |  |  | 42 |  |  |  |  |  |
Development and Regulatory Milestone | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | $ 138,200,000 |  |  | $ 138,200,000 |  |  |  | $ 290,500,000 |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.031 |  |  | 0.031 |  |  |  | 0.022 |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.053 |  |  | 0.053 |  |  |  | 0.047 |  |
Development and Regulatory Milestone | Agilis | Measurement Input, Discount Rate | Weighted Average | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 4.2 |  |  | 4.2 |  |  |  |  |  |
Development and Regulatory Milestone | Agilis | Probability of Success | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.25 |  |  | 0.25 |  |  |  | 0.25 |  |
Development and Regulatory Milestone | Agilis | Probability of Success | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.94 |  |  | 0.94 |  |  |  | 0.94 |  |
Liability, Net Sales Milestones and Royalties | Probability of Success | Weighted Average | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 48 |  |  | 48 |  |  |  |  |  |
Liability, Net Sales Milestones and Royalties | Agilis |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Liability value |  | $ 95,900,000 |  |  | $ 95,900,000 |  |  |  | $ 65,800,000 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Measurement Input, Discount Rate | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.120 |  |  | 0.120 |  |  |  | 0.145 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Probability of Success | Minimum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.25 |  |  | 0.25 |  |  |  | 0.25 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Probability of Success | Maximum | Commitments |  |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |  |
Rights Exchange settlement |  | 0.94 |  |  | 0.94 |  |  |  | 0.89 |  |

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