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v3.20.2

Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2020 | Sep. 30, 2019
Cash flows from operating activities |  |
Net loss | $ (363,806) | $ (173,899)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities [Abstract] |  |
Depreciation and amortization | 31,088 | 22,903
Non-cash operating lease expense | 4,295 | 2,446
Non-cash finance lease amortization expense | 41,382 | 0
Non-cash royalty revenue related to sale of future royalties | (299) | 0
Non-cash interest expense on liability related to sale of future royalties | 14,557 | 0
Change in valuation of deferred and contingent consideration | 16,980 | 35,960
Settlement of deferred and contingent consideration | 10,613 | 0
Non-cash stock consideration, acquisition | 42,869 | 0
Unrealized gain on equity investment | (852) | (2,529)
Unrealized gain on ClearPoint convertible debt security | (633) | 0
Non-cash interest expense | 16,678 | 6,583
Loss on disposal of asset | 25 | 0
Amortization of discounts on investments, net | (559) | (1,374)
Amortization of debt issuance costs | 766 | 434
Share-based compensation expense | 48,909 | 30,668
Unrealized foreign currency transaction (gains) losses, net | (27,077) | 205
Changes in operating assets and liabilities: |  |
Inventory, net | 390 | (1,574)
Prepaid expenses and other current assets | (9,289) | (11,771)
Trade receivables, net | 121 | 5,879
Deposits and other assets | (217) | (1,073)
Accounts payable and accrued expenses | 54,390 | 695
Other liabilities | (4,096) | (3,567)
Deferred revenue | (5,940) | 1,581
Net cash used in operating activities | (129,705) | (88,433)
Cash flows from investing activities |  |
Purchases of fixed assets | (11,491) | (9,104)
Purchase of convertible debt security | (10,000) | 0
Purchases of marketable securities | (1,006,946) | (239,386)
Sale and redemption of marketable securities | 700,627 | 114,500
Acquisition of product rights and licenses | (25,618) | (20,250)
Purchase of equity investment | 0 | (4,000)
Net cash provided by (used in) investing activities | (353,428) | (158,240)
Cash flows from financing activities |  |
Proceeds from issuance of convertible notes | 0 | 279,571
Proceeds from exercise of options | 32,987 | 12,195
Termination and exit fees related to payoff of secured term loan | (597) | 0
Net proceeds from public offerings | 28,092 | 324,262
Repayment of senior secured term loan | (28,333) | (6,667)
Payments on deferred consideration obligation | (38,100) | 0
Proceeds from employee stock purchase plan | 2,406 | 1,564
Payment of finance lease principal | (17,829) | 0
Cash consideration received from Royalty Purchase Agreement | 650,000 | 0
Net cash provided by financing activities | 628,626 | 610,925
Effect of exchange rate changes on cash | 449 | (2,673)
Net decrease in cash and cash equivalents | 145,942 | 361,579
Cash and cash equivalents, and restricted cash beginning of period | 295,528 | 169,498
Cash and cash equivalents, and restricted cash end of period | 441,470 | 531,077
Supplemental disclosure of cash information |  |
Cash paid for interest | 9,802 | 7,042
Cash paid for income taxes | 1,562 | 1,931
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain on marketable securities, net of tax | 1,639 | 435
Right-of-use assets obtained in exchange for operating lease obligations | 76,657 | 16,120
Right-of-use assets obtained in exchange for finance lease obligations | 41,382 | 0
Acquisition of product rights and licenses | 13,786 | 7,432
Issuance of common stock related to rights exchange | 150,528 | 0
Accrued transaction costs related to public offerings | 0 | 506
Accrued transaction costs related to issuance of convertible notes | $ 0 | $ 298

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