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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 25 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2019 | May 31, 2019 | Sep. 30, 2020 | Sep. 30, 2019 | Sep. 30, 2020 | Sep. 30, 2019 | Dec. 31, 2019 | Sep. 30, 2020 | Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |  |
Useful life |  |  |  |  | 7 years |  |  |  |
Amortization of acquired intangible assets |  |  | $ 9,630 | $ 7,025 | $ 26,309 | $ 19,677 |  |  |
Total allocation of IPR&D assets |  |  |  |  | 576,500 |  |  |  |
Change in indefinite-lived intangibles |  |  |  |  |  |  |  | $ 0 |
Goodwill | $ 82,341 |  | 82,341 |  | 82,341 |  | $ 82,341 | $ 82,341 |
Research and development |  |  | 92,998 | $ 63,076 | 359,630 | 175,621 |  |  |
Changes in goodwill |  |  | $ 0 |  | $ 0 |  |  |  |
Weighted Average |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  |  |  | 3 years 8 months 12 days |  |  |  |
Akcea |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |  |
Upfront licensing fee |  |  |  |  | $ 12,000 |  |  |  |
Non-collaborative Arrangement Transactions | Akcea |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |  |
Milestone payments | $ 4,000 | $ 6,000 |  |  | $ 4,000 |  | $ 6,000 |  |
Useful life |  |  |  |  | 10 years |  |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |  |  |  |  |
Finite-Lived intangibles |  |  |  |  |  |  |  |  | $ 148,400
Milestone obligation payments made |  |  |  |  | $ 13,800 | $ 7,400 |  |  |

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