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Stock award plan - (Tables)
9 Months Ended
Sep. 30, 2020
Share-based Payment Arrangement [Abstract]  
Summary of stock option activity

    

    

    

Weighted-

    

  

Weighted-

average

Aggregate

average

remaining

intrinsic

Number of

exercise

contractual

value(in 

options

price

term

thousands)

 

Outstanding at December 31, 2019

 

11,043,939

$

31.67

 

  

 

  

Granted

 

2,671,660

$

50.76

 

  

 

  

Exercised

 

(1,426,026)

$

23.14

 

  

 

  

Forfeited/Cancelled

 

(761,332)

$

42.96

 

  

 

  

Outstanding at September 30, 2020

 

11,528,241

$

36.37

 

7.32

years

$

138,286

Vested or Expected to vest at September 30, 2020

 

5,297,899

$

40.09

 

8.70

years

$

44,050

Exercisable at September 30, 2020

 

5,576,283

$

32.19

 

5.84

years

$

90,361

Schedule of assumptions used to estimate fair values of grants made on the date of grant

    

Nine months ended

    

    

September 30, 2020

    

Risk-free interest rate

 

0.34% - 1.45%

 

Expected volatility

 

87.50% - 89.31%

 

Expected term

 

5.75 years

 

Summary of information on the Company's restricted stock

Restricted Stock Awards and Units

Weighted

Average

Grant

Number of

Date

    

Shares

    

Fair Value

January 1, 2020

642,419

$

24.50

Granted

 

625,390

$

50.76

Vested

 

(232,263)

$

23.86

Forfeited

 

(73,751)

$

36.28

Unvested at September 30, 2020

 

961,795

$

41.05

Schedule of share-based compensation expense recorded in the statement of operations

Three Months Ended September 30, 

Nine Months Ended September 30, 

    

2020

    

2019

    

2020

    

2019

Research and development

$

9,220

$

4,988

$

25,961

$

15,191

Selling, general and administrative

 

7,559

 

5,496

 

22,948

 

15,477

Total

$

16,779

$

10,484

$

48,909

$

30,668