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The Company (Details) - USD ($) $ in Thousands				3 Months Ended	9 Months Ended
	Jun. 29, 2020	Apr. 29, 2020	Aug. 23, 2018	Sep. 30, 2020	Sep. 30, 2020	Dec. 31, 2019	Apr. 20, 2017	Aug. 31, 2015
Long-term debt
Retained earnings (accumulated deficit)				$ (1,554,523)	$ (1,554,523)	$ (1,190,499)
Rights Exchange Agreement
Long-term debt
Shares to issue under Rights Exchange Agreement		2,821,176		2,821,176	2,821,176
Cash consideration payment under Rights Exchange Agreement		$ 36,900
Convertible debt | 1.50% Convertible senior notes due 2026
Long-term debt
Interest rate ( as a percent )				1.50%	1.50%	1.50%
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Interest rate ( as a percent )								3.00%
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Long-term debt
Development milestone payments which the entity is obligated to pay							$ 50,000
Agilis
Long-term debt
Cash consideration			$ 49,200
Equity Interest Issued, number of shares (in shares)			3,500,907
Numerator for calculation of number of shares of equity interests issued to acquire entity			$ 150,000
Trading day period			10 days
Development milestone payments which the entity is obligated to pay		40,000		$ 40,000	$ 40,000
Development milestone payment obligations, net of cancellation and forfeiture					$ 20,000
Milestone obligation payments made				$ 2,400
Net sales amount		150,000
Agilis | Minimum
Long-term debt
Development milestone payments which the entity is obligated to pay	$ 37,600	$ 37,600
Product sales		2.00%		2.00%	2.00%
Agilis | Maximum
Long-term debt
Development milestone payments which the entity is obligated to pay	40,000			$ 60,000	$ 60,000
Priority review voucher amount					535,000
Net sales amount				$ 150,000	$ 150,000
Product sales		6.00%		6.00%	6.00%
Agilis | Rights Exchange Agreement
Long-term debt
Contingent liability, cancellation and forfeiture	$ 211,600	$ 211,600
Priority review voucher amount		174,000
Development milestone payment obligations, net of cancellation and forfeiture		20,000
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture		$ 361,000
Agilis | Rights Exchange Agreement | Maximum
Long-term debt
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture					$ 361,000
Agilis | Non-collaborative Arrangement Transactions
Long-term debt
Development milestone payments which the entity is obligated to pay				$ 40,000	$ 40,000

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