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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Sep. 30, 2020	Dec. 31, 2019
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 34,485	$ 38,390
Income tax payable	21,475	499
Consulting and contracted research	17,659	12,969
Professional fees	4,590	3,562
Sales allowance and other costs	50,644	41,155
Sales rebates and royalties	68,628	42,997
Accounts payable	15,663	10,324
Other	5,417	9,380
Accounts payable and accrued expenses	$ 218,561	$ 159,276

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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