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Stock award plan - Share Base Compensation (Details) - Stock option - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended
Sep. 30, 2020
Number of options  
Outstanding at the beginning of the period (in shares) 11,043,939
Granted (in shares) 2,671,660
Exercised (in shares) (1,426,026)
Forfeited/Cancelled (in shares) (761,332)
Outstanding at the end of the period (in shares) 11,528,241
Vested or Expected to vest at the end of the period (in shares) 5,297,899
Exercisable at the end of the period (in shares) 5,576,283
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) $ 31.67
Granted (in dollars per share) 50.76
Exercised (in dollars per share) 23.14
Forfeited/Cancelled (in dollars per share) 42.96
Outstanding at the end of the period (in dollars per share) 36.37
Vested or Expected to vest at the end of the period (in dollars per share) 40.09
Exercisable at the end of the period (in dollars per share) $ 32.19
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 3 months 25 days
Vested or Expected to vest at the end of the period 8 years 8 months 12 days
Exercisable at the end of the period 5 years 10 months 2 days
Aggregate intrinsic value (in thousands)  
Outstanding at the end of the period (in dollars) $ 138,286
Vested or Expected to vest at the end of the period (in dollars) 44,050
Exercisable at the end of the period (in dollars) $ 90,361
Valuation assumptions  
Expected term (in years) 5 years 9 months
Minimum  
Valuation assumptions  
Risk-free interest rate (as a percent) 0.34%
Expected volatility (as a percent) 87.50%
Maximum  
Valuation assumptions  
Risk-free interest rate (as a percent) 1.45%
Expected volatility (as a percent) 89.31%