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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Total
Balance (in shares) at Dec. 31, 2018 50,606,147        
Balance at the beginning of the period at Dec. 31, 2018 $ 51 $ 1,288,137 $ 1,462 $ (938,923) $ 350,727
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares) 10,102,899        
Issuance of common stock related to equity offering $ 10 323,746     323,756
Equity component of the convertible notes issuance, net   119,489     119,489
Issuance of common stock related to rights exchange         0
Exercised (in shares) 645,435        
Exercise of options   12,195     12,195
Restricted stock vesting and issuance, net (in shares) 169,792        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 54,719        
Issuance of common stock in connection with an employee stock purchase plan   1,564     1,564
Share-based compensation expense   30,668     30,668
Net loss       (173,899) (173,899)
Comprehensive loss     (846)   (846)
Balance (in shares) at Sep. 30, 2019 61,578,992        
Balance at the end of the period at Sep. 30, 2019 $ 61 1,775,799 616 (1,112,822) 663,654
Balance (in shares) at Jun. 30, 2019 58,707,185        
Balance at the beginning of the period at Jun. 30, 2019 $ 58 1,539,530 1,922 (1,052,825) 488,685
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares) 2,539,174        
Issuance of common stock related to equity offering $ 3 99,208     99,211
Equity component of the convertible notes issuance, net   119,489     119,489
Exercised (in shares) 334,433        
Exercise of options   7,088     7,088
Restricted stock vesting and issuance, net (in shares) (1,800)        
Share-based compensation expense   10,484     10,484
Net loss       (59,997) (59,997)
Comprehensive loss     (1,306)   (1,306)
Balance (in shares) at Sep. 30, 2019 61,578,992        
Balance at the end of the period at Sep. 30, 2019 $ 61 1,775,799 616 (1,112,822) 663,654
Balance (in shares) at Dec. 31, 2019 61,935,870        
Balance at the beginning of the period at Dec. 31, 2019 $ 62 1,795,351 (10,584) (1,190,499) 594,330
Balance (in shares) at Jun. 30, 2020 67,240,679        
Balance at the end of the period at Jun. 30, 2020 $ 67 2,067,274 (10,016) (1,484,831) 572,494
Balance (in shares) at Dec. 31, 2019 61,935,870        
Balance at the beginning of the period at Dec. 31, 2019 $ 62 1,795,351 (10,584) (1,190,499) 594,330
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares) 542,470        
Issuance of common stock related to equity offering $ 1 28,091     28,092
Payments for asset acquisitions, shares (in shares) 845,364        
Payments for asset acquisitions, share, value $ 1 42,868     42,869
Issuance of common stock related to rights exchange (in shares) 2,821,176        
Issuance of common stock related to rights exchange $ 3 150,525     150,528
Exercised (in shares) 1,426,026        
Exercise of options $ 1 32,986     32,987
Restricted stock vesting and issuance, net (in shares) 179,963        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 58,691        
Issuance of common stock in connection with an employee stock purchase plan   2,406     2,406
Share-based compensation expense   48,909     48,909
Other       (218) (218)
Net loss       (363,806) (363,806)
Comprehensive loss     (25,143)   (25,143)
Balance (in shares) at Sep. 30, 2020 67,809,560        
Balance at the end of the period at Sep. 30, 2020 $ 68 2,101,136 (35,727) (1,554,523) 510,954
Balance (in shares) at Jun. 30, 2020 67,240,679        
Balance at the beginning of the period at Jun. 30, 2020 $ 67 2,067,274 (10,016) (1,484,831) 572,494
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares) 173,956        
Issuance of common stock related to equity offering   9,141     9,141
Exercised (in shares) 391,738        
Exercise of options $ 1 7,942     7,943
Restricted stock vesting and issuance, net (in shares) 3,187        
Share-based compensation expense   16,779     16,779
Net loss       (69,692) (69,692)
Comprehensive loss     (25,711)   (25,711)
Balance (in shares) at Sep. 30, 2020 67,809,560        
Balance at the end of the period at Sep. 30, 2020 $ 68 $ 2,101,136 $ (35,727) $ (1,554,523) $ 510,954