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Commitments and contingencies - Narrative (Details) - USD ($) $ in Millions			1 Months Ended		3 Months Ended	9 Months Ended	12 Months Ended
	Jun. 29, 2020	Apr. 29, 2020	Dec. 31, 2019	May 31, 2019	Sep. 30, 2020	Sep. 30, 2020	Dec. 31, 2019	May 29, 2020	Apr. 20, 2017	Jun. 30, 2016
Akcea
Other Commitments [Abstract]
Upfront licensing fee						$ 12.0
Akcea | Maximum
Other Commitments [Abstract]
Milestone payments							$ 4.0
Censa
Other Commitments [Abstract]
Asset acquisition, milestone, amount								$ 217.5
Asset acquisition, development and regulatory milestones								109.0
Asset acquisition, net sales milestone								160.0
Asset acquisition, initial milestone								30.0
Censa | Maximum
Other Commitments [Abstract]
Asset acquisition, milestone, amount								$ 217.5
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay									$ 50.0
Non-collaborative Arrangement Transactions | Akcea
Other Commitments [Abstract]
Milestone payments			$ 4.0	$ 6.0		4.0	$ 6.0
Agilis
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay		$ 40.0			$ 40.0	40.0
Net sales amount		150.0
Milestone obligation payments made					2.4
Development milestone payment obligations, net of cancellation and forfeiture						20.0
Development milestone obligation payments made					2.4
Agilis | Rights Exchange Agreement
Other Commitments [Abstract]
Priority review voucher amount		174.0
Contingent Liability cancellation and forfeiture, Milestone, Potential Achievements, Priority Review Voucher Amount						174.0
Development milestone payment obligations, cancellation and forfeiture						37.6
Development milestone payment obligations, net of cancellation and forfeiture		20.0
Contingent liability, cancellation and forfeiture	$ 211.6	211.6
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture		$ 361.0
Agilis | Maximum
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay	40.0				60.0	60.0
Priority review voucher amount						535.0
Net sales amount					$ 150.0	$ 150.0
Product sales		6.00%			6.00%	6.00%
Agilis | Maximum | Rights Exchange Agreement
Other Commitments [Abstract]
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture						$ 361.0
Agilis | Minimum
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay	$ 37.6	$ 37.6
Product sales		2.00%			2.00%	2.00%
Agilis | Non-collaborative Arrangement Transactions
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay					$ 40.0	$ 40.0
BioElectron | Maximum
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay					200.0	200.0
Net product revenue | Wellcome trust
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay										$ 0.8
Net product revenue | Wellcome trust | Maximum
Other Commitments [Abstract]
Development milestone payments which the entity is obligated to pay					$ 22.4	$ 22.4

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