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Fair value of financial instruments and marketable securities - Fair Value Measurement Inputs and Valuation Techniques (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019
Significant unobservable inputs (level 3)
Level 3 roll forward
Additions		$ 0
SARs
Level 3 roll forward
Ending Balance	$ 0
SARs | Significant unobservable inputs (level 3)
Level 3 roll forward
Beginning Balance	3,186	3,814
Additions	0
Change in fair value	0	2,236
Payments	(3,186)	(3,815)
Ending Balance	0	2,235
Commitments | Significant unobservable inputs (level 3)
Level 3 roll forward
Beginning Balance	290,500	257,040
Additions	0	0
Change in fair value	(13,120)	28,260
Payments	0	0
Ending Balance	138,200	285,300
Liability, Net Sales Milestones and Royalties | Agilis
Level 3 roll forward
Beginning Balance	65,800
Ending Balance	95,900
Liability, Net Sales Milestones and Royalties | Agilis | Significant unobservable inputs (level 3)
Level 3 roll forward
Beginning Balance	65,800	53,200
Additions	0	0
Change in fair value	30,100	6,400
Payments	0	0
Ending Balance	$ 95,900	$ 59,600

X

- Definition

Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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- Definition

Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(2)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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- Definition

Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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- Definition

A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

+ References

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