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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Jan. 31, 2020	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Stock option plan
Share-based compensation expense		$ 16,779	$ 10,484	$ 48,909	$ 30,668
Research and development
Stock option plan
Share-based compensation expense		9,220	4,988	25,961	15,191
Selling, general and administrative
Stock option plan
Share-based compensation expense		$ 7,559	$ 5,496	$ 22,948	$ 15,477
Common stock
Stock option plan
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		935,092		935,092
Common stock | 2020 inducement stock incentive plan [Member]
Stock option plan
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number	1,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		291,025		291,025

X

- Definition

Represents the number of shares to be added annually on the first day of each fiscal year in the number of shares authorized.

+ References

No definition available.

+ Details

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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