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Revenue recognition - Narrative (Details) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Aug. 31, 2020 USD ($)	Sep. 30, 2020 USD ($) Distributor	Sep. 30, 2019 USD ($) Distributor	Sep. 30, 2020 USD ($) Distributor segment	Sep. 30, 2019 USD ($) Distributor	Jul. 17, 2020 USD ($)	Nov. 30, 2011 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of operating segments | segment				1
Percentage of net product sales		10.00%	10.00%	10.00%	10.00%
Number of distributors | Distributor		2	2	2	2
Revenue recognition, milestone, potential achievements						$ 362,500
Revenue		$ 118,404	$ 71,416	$ 261,902	$ 210,521
Performance obligations satisfied in period		2,000	2,300	6,000	2,300
Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue		35,000	100	35,100	100
Licensing And Collaboration Agreement | Research And Development Event Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements		37,500		37,500			$ 135,000
Milestone payments received	$ 15,000
Licensing And Collaboration Agreement | Sales Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements		325,000		325,000			$ 325,000
Milestone payments received	$ 20,000
Royalty revenue
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue		696	0	696	0
United States
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product revenue		38,500	22,900	102,100	68,300
Non-US
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product revenue		$ 44,200	$ 48,500	$ 124,000	$ 141,600

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Revenue Recognition, Milestone, Potential Achievements

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Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

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Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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