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Income taxes - Tax Rate Reconciliation (Details) | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate |  |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 21.00%
State income tax provision, net of federal benefit | (3.31%) | 1.08% | 0.05%
Permanent differences | (6.66%) | (6.17%) | (6.41%)
Research and development | 4.93% | 4.38% | 6.49%
Change in valuation allowances | (26.40%) | (35.49%) | 2.20%
Change in deferred tax assets | 0.0293 | 0.1589 | (0.1422)
Foreign tax rate differential | 0.72% | (1.88%) | (9.10%)
Tax rate change | (1.46%) | (3.67%) |
(Accrual) release of uncertain tax positions | (0.61%) |  |
Other | 0.12% |  | 0.01%
Effective income tax rate | (8.74%) | (4.86%) | 0.02%

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