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Income taxes (Tables) | 12 Months Ended
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Dec. 31, 2020
Income Tax Disclosure [Abstract] |
Schedule of Income before Income Tax, Domestic and Foreign | The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2020, 2019, and 2018: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2020 |  | 2019 |  | 2018
Domestic | ​ | $ | (452,475) | ​ | $ | (231,915) | ​ | $ | (68,461)
Foreign | ​ |  | 49,543 | ​ |  | (8,011) | ​ |  | (59,649)
Total | ​ | $ | (402,932) | ​ | $ | (239,926) | ​ | $ | (128,110)
​
Components of Income Tax Provision | The Income Tax Provision consisted of the following for the years ended December 31, 2020, 2019 and 2018: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2020 |  | 2019 |  | 2018
Current: |  | ​ |  |  | ​ |  |  | ​ |
U.S. Federal | ​ | $ | — | ​ | $ | — | ​ | $ | —
U.S. State and Local | ​ |  | (24,984) | ​ |  | (61) | ​ |  | (38)
Foreign | ​ |  | (4,372) | ​ |  | (2,041) | ​ |  | (669)
Deferred: | ​ |  |  | ​ |  |  | ​ |  |
U.S. Federal | ​ |  | — | ​ |  | — | ​ |  | —
U.S. State and Local | ​ |  | (5,872) | ​ |  | (8,812) | ​ |  | —
Foreign | ​ |  | — | ​ |  | (736) | ​ |  | 736
Total tax benefit (expense) | ​ | $ | (35,228) | ​ | $ | (11,650) | ​ | $ | 29
Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate | A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31, |
​ |  | 2020 |  | 2019 |  | 2018 |
Federal income tax provision at statutory rate | ​ | 21.00 | % | 21.00 | % | 21.00 | %
State income tax provision, net of federal benefit | ​ | (3.31) |  | 1.08 |  | 0.05 | ​
Permanent differences | ​ | (6.66) |  | (6.17) |  | (6.41) | ​
Research and development | ​ | 4.93 |  | 4.38 |  | 6.49 | ​
Change in valuation allowances | ​ | (26.40) |  | (35.49) |  | 2.20 | ​
Change in deferred tax assets | ​ | 2.93 |  | 15.89 |  | (14.22) | ​
Foreign tax rate differential | ​ | 0.72 |  | (1.88) |  | (9.10) | ​
Tax rate change | ​ | (1.46) |  | (3.67) |  | — | ​
(Accrual) Release of uncertain tax positions | ​ | (0.61) | ​ | — | ​ | — | ​
Other | ​ | 0.12 |  | — |  | 0.01 | ​
Effective income tax rate | ​ | (8.74) | % | (4.86) | % | 0.02 | %
​
Schedule of significant components of the Company's deferred tax assets and liabilities | The amount of deferred income taxes are as follows: The significant components of the Company’s deferred tax assets and liabilities at December 31, 2020 and 2019 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2020 |  | 2019
Deferred tax assets: |  | ​ |  |  | ​ |
Accrued expense | ​ | $ | 5,528 | ​ | $ | 2,588
Amortization | ​ |  | 80,677 | ​ |  | 78,291
Depreciation | ​ |  | — | ​ |  | 991
Federal tax credits | ​ |  | 123,405 | ​ |  | 99,421
State tax credits | ​ |  | — | ​ |  | 6,489
Federal net operating losses | ​ |  | 16,999 | ​ |  | 91,010
State net operating losses | ​ |  | 1,428 | ​ |  | 1,360
Foreign net operating losses | ​ |  | — | ​ |  | 1,056
Capitalized research and development costs | ​ |  | 661 | ​ |  | 1,274
Share based compensation and other | ​ |  | 14,612 | ​ |  | 16,425
Liability for sale of future royalties | ​ | ​ | 161,204 | ​ | ​ | —
Other comprehensive loss | ​ |  | 7,624 | ​ |  | 1,512
Total gross deferred tax assets | ​ |  | 412,138 | ​ |  | 300,417
Less valuation allowance | ​ |  | (379,608) | ​ |  | (267,131)
Total deferred tax assets, net of valuation allowance | ​ | $ | 32,530 | ​ | $ | 33,286
Deferred tax liabilities: | ​ |  |  | ​ |  |
Depreciation | ​ | $ | (2,904) | ​ | $ | —
Convertible debt | ​ | ​ | (29,626) | ​ | ​ | (33,286)
Indefinite lived intangible | ​ |  | (136,735) | ​ |  | (130,862)
Total gross deferred tax liabilities | ​ |  | (169,265) | ​ |  | (164,148)
Net deferred tax assets (liabilities) | ​ | $ | (136,735) | ​ | $ | (130,862)
​
Schedule of uncertain income tax benefits | A reconciliation of the gross amount of unrecognized tax benefits, excluding accrued interest and penalties, is as follows:
​ | ​ | ​
​ | Unrecognized Tax Benefits
Balance at December 31, 2019 | ​ | —
Increase in tax positions for prior years |  | 2,446
Balance at December 31, 2020 | $ | 2,446

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