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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating loss carryforwards |  |  |
Taxable income before consideration of NOL | $ 364,100 |  |
State income tax provision | 24,984 | $ 61 | $ 38
Valuation allowance | 379,608 | 267,131 |
Valuation allowance, deferred tax asset, increase (decrease) | 112,500 | $ 86,700 |
Operating loss carryforwards limited by IRC Section 382 | 231,500 |  |
Orphan Drug Credit carryover | 107,700 |  |
Operating loss carryforwards, not subject to expiration | 169,200 |  |
Operating loss carryforwards, subject to expiration | 62,300 |  |
Net operating loss carryforwards utilized | 364,100 |  |
Operating loss carryforwards for immediate use | 9,500 |  |
Operating loss carryforwards in next twelve months | $ 5,700 |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 21.00%
Uncertain tax position | $ 0 |  |
Undistributed earnings from non-US subsidiaries | 16,100 |  |
Undistributed earnings from non-US subsidiaries, tax | 0 |  |
Provisional tax benefit from corporate tax rate reductions |  |  | $ 46,100
Increase in tax positions for prior years | 2,446 |  |
First five years from ownership change |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 16,700 |  |
After five years from ownership change |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 5,700 |  |
Federal |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 80,900 |  |
Research and development credit carryforwards | 15,700 |  |
Net operating loss carryforwards limited by IRC Section 382 utilized | 97,700 |  |
State |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | $ 22,600 |  |

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