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The Company (Details) - USD ($) $ in Thousands |  |  | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Apr. 29, 2020 | Aug. 23, 2018 | Dec. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Aug. 31, 2015
Long-term debt |  |  |  |  |  |
Contingent liability, cancellation and forfeiture | $ 211,600 |  |  |  |  |
Retained earnings (accumulated deficit) |  |  | $ (1,628,877) | $ (1,190,499) |  |
Convertible debt | 1.50% Convertible senior notes due 2026 |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Interest rate ( as a percent ) |  |  |  |  | 1.50% |
Convertible debt | 3.00% Convertible senior notes due 2022 |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Interest rate ( as a percent ) |  |  |  |  |  | 3.00%
Rights Exchange Agreement |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Shares issued under Rights Exchange Agreement | 2,821,176 |  | 2,821,176 |  |  |
Cash consideration payment under Rights Exchange Agreement | $ 36,900 |  | $ 36,900 |  |  |
Agilis |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Payments for asset acquisitions |  | $ 49,221 |  |  |  |
Equity Interest Issued, number of shares (in shares) |  | 3,500,907 |  |  |  |
Numerator for calculation of number of shares of equity interests issued to acquire entity |  | $ 150,000 |  |  |  |
Trading day period |  | 10 days |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  | $ 40,000 |  |  |
Net sales amount | $ 150,000 |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Product sales (as a percent) | 2.00% |  | 2.00% |  |  |
Agilis | Maximum |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 20,000 |  |  |  |  |
Priority review voucher amount |  |  | $ 535,000 |  |  |
Development milestone payment obligations, net of cancellation and forfeiture |  |  | 20,000 |  |  |
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture | 361,000 |  | 361,000 |  |  |
Net sales amount | $ 150,000 |  | $ 150,000 |  |  |
Product sales (as a percent) | 6.00% |  | 6.00% |  |  |
Agilis | Agilis Merger Agreement | Maximum |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Priority review voucher amount |  |  | $ 535,000 |  |  |
Agilis | Rights Exchange Agreement |  |  |  |  |  |
Long-term debt |  |  |  |  |  |
Contingent liability, cancellation and forfeiture |  |  | $ 211,600 |  |  |

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