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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Aug. 01, 2018 | Apr. 20, 2017 | May 31, 2019 | Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Aug. 23, 2018
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Amortization of acquired intangible assets |  |  |  |  |  | $ 36,892 | $ 27,650 | $ 22,877 |
Remaining amortization period |  |  |  |  |  | 3 years 6 months |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  |  | $ 0 |  |  |
Goodwill |  |  |  |  |  | 82,341 | 82,341 |  |
Impairment of goodwill |  |  |  |  |  | $ 0 |  |  |
Akcea |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  | 4,000 |  |
Upfront licensing fee | $ 12,000 |  | $ 6,000 |  |  |  | 6,000 | 12,000 |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Useful life |  |  | 10 years |  |  | 10 years |  |  |
Milestone payments |  |  | $ 6,000 |  |  |  | 4,000 |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Finite-lived intangibles |  | $ 148,400 |  |  |  |  |  |  |
Useful life |  | 7 years |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  | $ 40,900 | 27,100 | 14,400 |
Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  |  | 14,200 |  |  |
Agilis |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  |  | 40,000 |  |  |
Goodwill |  |  |  | $ 82,341 | $ 82,341 | 82,300 | $ 82,300 | 82,341 | $ 100,309
Goodwill adjustment |  |  |  | 18,000 | (17,968) |  |  |  |
Impairment of goodwill |  |  |  |  |  | 0 |  |  |
Agilis | Agilis Merger Agreement |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  |  | $ 40,000 |  |  | 40,000
In Process Research and Development | Agilis |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |
Intangible assets, other than goodwill |  |  |  | $ 576,500 | $ 576,500 |  |  | $ 576,500 | $ 480,000

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