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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Oct. 31, 2020 USD ($) | Aug. 31, 2020 USD ($) | Nov. 30, 2019 USD ($) | Nov. 30, 2011 USD ($) item | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  | $ 355,000 |  |  |  |  |  |  | $ 355,000 |  |
Revenue |  |  |  |  |  |  |  |  |  |  |  | 380,766 | $ 306,980 | $ 264,734
Collaboration revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 7,516 | $ 35,000 | $ 63 | $ 15,052 | $ 47 | $ 46 | $ 529 | 42,579 | 15,674 | 1,729
Royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 4,090 | $ 696 |  |  |  |  |  | 4,786 |  |
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Performance period |  |  |  | 2 years |  |  |  |  |  |  |  |  |  |
Deferred consideration payable |  |  |  | $ 30,000 |  |  |  |  |  |  |  |  |  |
Licensing And Collaboration Agreement | Collaboration revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  |  | 42,600 | 15,200 | 200
Licensing And Collaboration Agreement | Roche And SMA Foundation |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangements number of compounds in preclinical development | item |  |  |  | 3 |  |  |  |  |  |  |  |  |  |
Collaborative arrangements number of significant deliverables | item |  |  |  | 2 |  |  |  |  |  |  |  |  |  |
SMA License Agreement | Royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  |  | 4,800 | $ 0 | $ 0
Research And Development Event Milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  | 30,000 |  |  |  |  |  |  | 30,000 |  |
Milestone payments received | $ 7,500 | $ 15,000 | $ 15,000 |  |  |  |  |  |  |  |  |  |  |
Sales Milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  | $ 325,000 |  |  |  |  |  |  | $ 325,000 |  |
Milestone payments received |  | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |
Maximum | Research And Development Event Milestones | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  | $ 135,000 |  |  |  |  |  |  |  |  |  |

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