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Selected quarterly financial data (Unaudited) | 12 Months Ended
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Dec. 31, 2020
Quarterly Financial Information Disclosure [Abstract] |
Selected quarterly financial data (Unaudited) | 20. Selected quarterly financial data (Unaudited) The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2020 and 2019 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | For the quarters ending (1)
​ |  | March 31 |  | June 30 |  | September 30 |  | December 31
2020: | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net product revenue | ​ | $ | 68,196 | ​ | $ | 75,239 | ​ | $ | 82,708 | ​ | $ | 107,258
Collaboration revenue | ​ |  | 63 | ​ |  | — | ​ |  | 35,000 | ​ |  | 7,516
Royalty revenue | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 696 | ​ | ​ | 4,090
Operating expenses | ​ |  | 161,250 | ​ |  | 262,512 | ​ |  | 173,535 | ​ |  | 215,238
Loss income from operations | ​ |  | (92,991) | ​ |  | (187,273) | ​ |  | (55,131) | ​ |  | (96,374)
Net loss | ​ |  | (112,687) | ​ |  | (181,427) | ​ |  | (69,692) | ​ |  | (74,354)
Basic and diluted net loss per common share | ​ | $ | (1.81) | ​ | $ | (2.78) | ​ | $ | (1.03) | ​ | $ | (1.08)
2019: | ​ |  |  | ​ |  |  | ​ |  |  | ​ |  |
Net product revenue | ​ | $ | 53,054 | ​ | $ | 85,476 | ​ | $ | 71,369 | ​ | $ | 81,407
Collaboration revenue | ​ |  | 529 | ​ |  | 46 | ​ |  | 47 | ​ |  | 15,052
Operating expenses | ​ |  | 122,723 | ​ |  | 124,280 | ​ |  | 131,891 | ​ |  | 169,243
Loss from operations | ​ |  | (69,140) | ​ |  | (38,758) | ​ |  | (60,475) | ​ |  | (72,784)
Net loss | ​ |  | (72,113) | ​ |  | (41,789) | ​ |  | (59,997) | ​ |  | (77,677)
Basic and diluted net loss per common share | ​ | $ | (1.29) | ​ | $ | (0.75) | ​ | $ | (1.06) | ​ | $ | (1.37)
(1) | The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.

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- References No definition available. + Details
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- Definition The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -URI http://asc.fasb.org/topic&trid=2126967 + Details
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