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Summary of significant accounting policies - Narrative (Details) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Jul. 17, 2020 USD ($) | Jul. 31, 2020 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) segment | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Aug. 23, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Letters of Credit |  |  |  |  |  |  | $ 7,500 |  |  |  |  | $ 7,500 |  |  |
Number of operating segments | segment |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |
Number of reporting units | segment |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |
Allowance for credit loss |  |  | $ 0 |  |  |  |  |  |  |  | $ 0 |  |  |  |
Inventory write-down |  |  |  |  |  |  |  |  |  |  | 500 | 400 |  |  |
Operating lease ROU assets |  |  | 84,410 |  |  |  | 13,693 |  |  |  | 84,410 | 13,693 |  |  |
Stockholders equity |  |  | 481,982 |  |  |  | 594,330 |  |  |  | 481,982 | 594,330 | $ 350,727 | $ 156,437 |
Increase in allowance for credit losses |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Allowance for doubtful accounts receivable |  |  | 100 |  |  |  | 300 |  |  |  | 100 | 300 |  |  |
Unrealized foreign exchange gain on translation of intercompany loan |  |  |  |  |  |  |  |  |  |  | 54,600 |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | 380,766 | 306,980 | 264,734 |  |
Deferred payroll taxes provided for under CARES Act |  |  |  |  |  |  |  |  |  |  | 2,500 |  |  |  |
Cash consideration received from Royalty Purchase Agreement | $ 650,000 | $ 650,000 |  |  |  |  |  |  |  |  | 650,000 |  |  |  |
State income tax provision |  |  |  |  |  |  |  |  |  |  | 24,984 | 61 | $ 38 |  |
Deferred research and development advance payments |  |  | 4,700 |  |  |  | 4,500 |  |  |  | $ 4,700 | $ 4,500 |  |  |
Federal income tax statutory rate |  |  |  |  |  |  |  |  |  |  | 21.00% | 21.00% | 21.00% |  |
Deferred tax liability |  |  | 122,000 |  |  |  |  |  |  |  | $ 122,000 |  |  |  |
Impairment of long-lived assets |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Impairment of goodwill |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Total |  |  | 86,964 |  |  |  | 14,171 |  |  |  | 86,964 | $ 14,171 |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Term for letter of credit (in years) |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred tax liability |  |  |  |  |  |  |  |  |  |  |  |  | $ 122,032 |  | $ 115,200
Impairment of goodwill |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Fifth Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Letters of Credit |  |  |  |  |  |  | 3,800 |  |  |  |  | $ 3,800 |  |  |
Term for letter of credit (in years) |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |
Non-US |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | 194,370 | $ 190,304 |  |  |
United States |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | 186,396 | 116,676 |  |  |
Net product revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  | 107,258 | $ 82,708 | $ 75,239 | $ 68,196 | 81,407 | $ 71,369 | $ 85,476 | $ 53,054 | 333,401 | 291,306 | 263,005 |  |
Net product revenue | Non-US |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | 194,400 | 190,300 | 171,000 |  |
Net product revenue | United States |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  |  | 139,000 | 101,000 | 92,000 |  |
Cumulative Effect Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders equity |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,266 |
ASC 606 Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,900 |
Variable consideration of accounting principle |  |  |  |  |  |  |  |  |  |  |  |  |  | 600 |
Accumulated deficit |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders equity |  |  | $ (1,628,877) |  |  |  | $ (1,190,499) |  |  |  | $ (1,628,877) | $ (1,190,499) | $ (938,923) | (814,108) |
Accumulated deficit | Cumulative Effect Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders equity |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,266 |

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