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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Common stock | Additional paid-in capital | Accumulated other comprehensive income (loss) | Accumulated deficit Cumulative Effect Adjustment | Accumulated deficit | Cumulative Effect Adjustment | Total
--- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2017 | 41,612,395 |  |  |  |  |  |
Balance at the beginning of the period at Dec. 31, 2017 | $ 42 | $ 966,534 | $ 3,969 | $ 3,266 | $ (814,108) | $ 3,266 | $ 156,437
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Issuance of common stock related to equity offerings (in shares) | 4,600,000 |  |  |  |  |  |
Issuance of common stock related to equity offering | $ 5 | 117,911 |  |  |  |  | 117,916
Issuance of common stock related to acquisition (in shares) | 3,500,907 |  |  |  |  |  |
Issuance of common stock related to acquisition | $ 3 | 155,857 |  |  |  |  | 155,860
Exercise of options (in shares) | 633,973 |  |  |  |  |  |
Exercise of options | $ 1 | 10,867 |  |  |  |  | 10,868
Restricted stock vesting and issuance (in shares) | 119,691 |  |  |  |  |  |
Restricted stock vesting and issuance, net |  |  |  |  |  |  | 0
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 139,181 |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  | 2,787 |  |  |  |  | 2,787
Share-based compensation expense |  | 33,252 |  |  |  |  | 33,252
Receivable from investor |  | 929 |  |  |  |  | 929
Net loss |  |  |  |  | (128,081) |  | (128,081)
Comprehensive loss |  |  | (2,507) |  |  |  | (2,507)
Balance (in shares) at Dec. 31, 2018 | 50,606,147 |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2018 | $ 51 | 1,288,137 | 1,462 |  | (938,923) |  | 350,727
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Issuance of common stock related to equity offerings (in shares) | 10,102,899 |  |  |  |  |  |
Issuance of common stock related to equity offering | $ 10 | 323,746 |  |  |  |  | 323,756
Equity component of convertible notes, net |  | 119,482 |  |  |  |  | 119,482
Exercise of options (in shares) | 949,887 |  |  |  |  |  |
Exercise of options | $ 1 | 18,275 |  |  |  |  | 18,276
Restricted stock vesting and issuance (in shares) | 169,792 |  |  |  |  |  |
Restricted stock vesting and issuance, net |  |  |  |  |  |  | 0
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 107,145 |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  | 3,577 |  |  |  |  | 3,577
Share-based compensation expense |  | 42,134 |  |  |  |  | 42,134
Net loss |  |  |  |  | (251,576) |  | (251,576)
Comprehensive loss |  |  | (12,046) |  |  |  | (12,046)
Balance (in shares) at Dec. 31, 2019 | 61,935,870 |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2019 | $ 62 | 1,795,351 | (10,584) |  | (1,190,499) |  | 594,330
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Issuance of common stock related to equity offerings (in shares) | 542,470 |  |  |  |  |  |
Issuance of common stock related to equity offering | $ 1 | 28,091 |  |  |  |  | 28,092
Issuance of common stock related to acquisition (in shares) | 845,364 |  |  |  |  |  |
Issuance of common stock related to acquisition | $ 1 | 42,868 |  |  |  |  | 42,869
Issuance of common stock related to rights exchange (in shares) | 2,821,176 |  |  |  |  |  |
Issuance of common stock related to rights exchange | $ 3 | 150,525 |  |  |  |  | 150,528
Exercise of options (in shares) | 3,268,452 |  |  |  |  |  |
Exercise of options | $ 3 | 70,176 |  |  |  |  | 70,179
Restricted stock vesting and issuance (in shares) | 180,028 |  |  |  |  |  |
Restricted stock vesting and issuance, net |  |  |  |  |  |  | 0
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 124,736 |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  | 5,303 |  |  |  |  | 5,303
Share-based compensation expense |  | 70,325 |  |  |  |  | 70,325
Receivable from investor |  | 9,107 |  |  |  |  | 9,107
Other |  |  |  |  | (218) |  | (218)
Net loss |  |  |  |  | (438,160) |  | (438,160)
Comprehensive loss |  |  | (50,373) |  |  |  | (50,373)
Balance (in shares) at Dec. 31, 2020 | 69,718,096 |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2020 | $ 70 | $ 2,171,746 | $ (60,957) |  | $ (1,628,877) |  | $ 481,982

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