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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities |  |  |
Net loss | $ (438,160) | $ (251,576) | $ (128,081)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 43,490 | 32,180 | 26,087
Non-cash operating lease expense | 6,084 | 3,709 |
Non-cash finance lease amortization expense | 41,382 |  |
Non-cash royalty revenue related to sale of future royalties | (2,055) |  |
Non-cash interest expense on liability related to sale of future royalties | 31,817 |  |
Change in valuation of deferred and contingent consideration | 23,280 | 48,360 | 19,340
Settlement of deferred and contingent consideration | 10,613 |  |
Non-cash stock consideration, acquisition | 42,869 |  |
Unrealized gain on equity investment in ClearPoint | (14,310) | (2,194) |
Unrealized gain on ClearPoint convertible debt security | (19,252) |  |
Amortization of discounts on investments, net | 409 | (1,922) | (433)
Amortization of debt issuance costs | 1,020 | 694 | 524
Share-based compensation expense | 70,325 | 42,134 | 33,252
Non-cash interest expense | 22,598 | 12,027 | 7,518
Disposal of asset | 16 | 312 | 2
Deferred income taxes | 5,872 | 8,829 |
Unrealized foreign currency transaction (gains) losses, net | (56,980) | (11,619) | (59)
Changes in operating assets and liabilities: |  |  |
Inventory, net | 1,841 | (3,456) | (5,823)
Prepaid expenses and other current assets | (12,621) | (8,835) | (1,609)
Trade receivables, net | (10,483) | 11,525 | (29,589)
Deposits and other assets | (662) | (484) | (1,093)
Accounts payable and accrued expenses | 70,798 | 26,836 | 43,877
Other liabilities | (3,930) | (3,771) | 1,932
Deferred revenue | (8,032) | (1,388) | 6,514
Net cash used in operating activities | (194,071) | (98,639) | (27,641)
Cash flows from investing activities |  |  |
Purchases of fixed assets | (17,843) | (13,757) | (7,097)
Purchase of convertible debt security | (10,000) |  |
Purchases of marketable securities | (1,439,665) | (494,068) | (68,614)
Sale and redemption of marketable securities | 944,094 | 156,270 | 90,423
Acquisition of product rights and licenses | (38,134) | (31,682) | (8,433)
Purchase of equity investment |  | (4,000) |
Business acquisition, net of cash acquired |  |  | (48,892)
Net cash provided by (used in) investing activities | (561,548) | (387,237) | (42,613)
Cash flows from financing activities |  |  |
Proceeds from issuance of convertible notes |  | 279,267 |
Proceeds from exercise of options | 70,179 | 18,276 | 10,868
Termination and exit fees related to payoff of secured term loan | (597) |  |
Net proceeds from public offerings | 28,092 | 323,756 | 117,916
Repayment of senior secured term loan | (28,333) | (11,667) |
Payments on deferred consideration obligation | (38,100) |  |
Proceeds from employee stock purchase plan | 5,303 | 3,577 | 2,787
Payment of finance lease principal | (17,829) |  |
Cash consideration received from Royalty Purchase Agreement | 650,000 |  |
Net cash provided by financing activities | 668,715 | 613,209 | 131,571
Effect of exchange rate changes on cash | 7,688 | (1,303) | (3,611)
Net decrease in cash and cash equivalents | (79,216) | 126,030 | 57,706
Cash and cash equivalents, and restricted cash beginning of period | 295,528 | 169,498 | 111,792
Cash and cash equivalents, and restricted cash end of period | 216,312 | 295,528 | 169,498
Supplemental disclosure of cash information |  |  |
Cash paid for interest | 9,802 | 7,693 | 7,773
Cash paid for income taxes | 26,397 | 2,109 | 1,583
Supplemental disclosure of non-cash investing and financing activity |  |  |
Unrealized gain on marketable securities, net of tax of $0, $165, and $2, respectively | 1,145 | 724 | 9
Right-of-use assets obtained in exchange for operating lease obligations | 76,811 | 17,389 |
Right-of-use assets obtained in exchange for finance lease obligations | 41,382 |  |
Acquisition of product rights and licenses | 14,191 | $ 11,434 | $ 5,981
Issuance of common stock related to rights exchange | 150,528 |  |
Capital expenditures unpaid at the end of period | $ 1,060 |  |

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X
- References No definition available. + Details
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Namespace Prefix: | us-gaap_
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