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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:      
Revenue $ 380,766 $ 306,980 $ 264,734
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible assets 18,942 12,135 12,670
Amortization of acquired intangible assets 36,892 27,650 22,877
Research and development 477,643 257,452 171,984
Selling, general and administrative 245,164 202,541 153,548
Change in the fair value of deferred and contingent consideration 23,280 48,360 19,340
Settlement of deferred and contingent consideration 10,613    
Total operating expenses 812,534 548,138 380,419
Loss from operations (431,768) (241,158) (115,685)
Interest expense, net (56,352) (12,491) (12,554)
Other income, net 85,188 13,723 129
Loss before income tax expense (402,932) (239,926) (128,110)
Income tax (expense) benefit (35,228) (11,650) 29
Net loss attributable to common stockholders $ (438,160) $ (251,576) $ (128,081)
Weighted-average shares outstanding:      
Basic and diluted (in shares) 66,027,908 58,863,185 46,576,313
Net loss per share-basic and diluted (in dollars per share)      
Net loss per share-basic and diluted (in dollars per share) $ (6.64) $ (4.27) $ (2.75)
Net product revenue      
Revenues:      
Revenue $ 333,401 $ 291,306 $ 263,005
Collaboration revenue      
Revenues:      
Revenue 42,579 $ 15,674 $ 1,729
Royalty revenue      
Revenues:      
Revenue $ 4,786