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Acquisitions - BioElectron Acquisition (Details) - USD ($) $ in Thousands		12 Months Ended
	Oct. 25, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Acquisitions
Research and development		$ 477,643	$ 257,452	$ 171,984
BioElectron
Acquisitions
Payments for asset acquisitions	$ 10,000
Loan advance	4,000
Escrow	1,500
Acquisition costs	500
Total consideration	$ 10,500
Research and development			$ 10,000
BioElectron | Maximum
Acquisitions
Development milestone payment obligations		$ 200,000

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