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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) $ in Thousands	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($)
SARs
Fair Value Valuation Inputs
Fair value	$ 0
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Option Volatility
Fair Value Valuation Inputs
SARs measurement input		0.2893
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Risk Free Interest Rate
Fair Value Valuation Inputs
SARs measurement input		0.0019
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Strike Price | Minimum
Fair Value Valuation Inputs
SARs measurement input | $ / shares		6.76
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Strike Price | Maximum
Fair Value Valuation Inputs
SARs measurement input | $ / shares		30.86
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Share Price
Fair Value Valuation Inputs
SARs measurement input | $ / shares		48.03
SARs | Valuation Technique, Option Pricing Model | Measurement Input, Expected Term
Fair Value Valuation Inputs
SARs measurement input | $ / shares		0.01
Level 3
Fair Value Valuation Inputs
Fair value	101,200
Level 3 | SARs
Fair Value Valuation Inputs
Fair value	$ 0	$ 3,186	$ 3,814
Development and Regulatory Milestone | Level 3 | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.42
Development and Regulatory Milestone | Level 3 | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.034
Net Sales Milestones and Royalties | Level 3 | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.48
Net Sales Milestones and Royalties | Level 3 | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.115
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	$ 0	0
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 381,000	$ 555,000
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25	0.25
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94	0.94
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.022	0.022
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.045	0.047
Agilis | Development and Regulatory Milestone | Level 3 | Contingent Consideration Payable
Fair Value Valuation Inputs
Fair value	$ 139,200	$ 290,500	257,040
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0	0
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 150,000	$ 150,000
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25	0.25
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94	0.89
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.02	0.02
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.06	0.06
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.115	0.145
Agilis | Net Sales Milestones and Royalties | Level 3 | Contingent Consideration Payable
Fair Value Valuation Inputs
Fair value	$ 101,200	$ 65,800	$ 53,200

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+ References

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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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