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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 53,291	$ 38,390
Income tax payable	4,315	499
Consulting and contracted research	18,250	12,969
Professional fees	3,614	3,562
Sales allowance	54,327	38,579
Sales rebates	63,774	29,268
Royalties	16,575	13,729
Accounts payable	18,665	10,324
Other	9,357	11,956
Accounts payable and accrued expenses	$ 242,168	$ 159,276

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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