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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Mar. 05, 2013
Dec. 31, 2020
May 31, 2016
May 31, 2013
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Jan. 31, 2020
Stock option plan                
Share-based compensation expense         $ 70,325 $ 42,134 $ 33,252  
Unrecognized compensation cost   $ 159,000     $ 159,000      
Weighted average remaining service period for recognition of unrecognized compensation cost         2 years 8 months 23 days      
Unvested restricted stock                
Stock option plan                
Granted (in shares)         663,045      
Stock option                
Stock option plan                
Granted (in shares)         2,777,975 3,977,995 3,181,623  
Forfeited (in shares)         889,785 518,527 461,934  
Expected dividend yield (as a percent)         0.00% 0.00% 0.00%  
Weighted average grant date fair value (in dollars per share)         $ 36.94 $ 23.05 $ 17.48  
Stock option | Maximum                
Stock option plan                
Vesting period         4 years      
SARs                
Stock option plan                
Granted (in shares)     897,290          
Vested (in shares)         132,136      
Vesting period     4 years          
Share-based compensation expense         $ 0      
Employee Stock Purchase Plan                
Stock option plan                
Number of shares authorized (in shares)   1,000,000     1,000,000      
Award requisite service period         6 months      
Share-based compensation expense         $ 1,900      
Employee Stock Purchase Plan | Minimum                
Stock option plan                
Purchase price of common stock, percent         85.00%      
Employee stock purchase plan, voting percentage limit         5.00%      
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan                
Stock option plan                
Number of shares available for issuance       122,296        
2009 Equity and Long Term Incentive Plan                
Stock option plan                
Number of shares available for issuance       0        
Number of additional shares authorized (in shares)       2,500,000        
2009 Equity and Long Term Incentive Plan | Stock option                
Stock option plan                
Stockholder's specified ownership percentage   10.00%     10.00%      
Expiration period         10 years      
2009 Equity and Long Term Incentive Plan | Stock option | Minimum                
Stock option plan                
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date   100.00%     100.00%      
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date   110.00%     110.00%      
2013 Stock Incentive Plan                
Stock option plan                
Number of shares authorized (in shares) 739,937              
Number of shares available for issuance 0              
2013 Stock Incentive Plan | Unvested restricted stock                
Stock option plan                
Granted (in shares) 735,324              
2013 Stock Incentive Plan | Stock option                
Stock option plan                
Granted (in shares) 4,613              
2013 Long Term Incentive Plan                
Stock option plan                
Number of shares available for issuance   941,381     941,381      
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number       2,500,000        
Annual increase in the number of shares outstanding on the first day of the fiscal year       4.00%        
2013 Long Term Incentive Plan | Maximum                
Stock option plan                
Number of shares subject to outstanding awards (in shares)       3,040,444        
2020 Inducement Stock Incentive Plan                
Stock option plan                
Number of shares available for issuance   1,186,005     1,186,005      
Number of additional shares authorized (in shares)   1,000,000            
2020 Inducement Stock Incentive Plan | Maximum                
Stock option plan                
Number of shares authorized (in shares)               1,000,000
2020 Inducement Stock Incentive Plan | Restricted stock units                
Stock option plan                
Granted (in shares)         73,645      
Inducement Grant Plan -Nasdaq exception | Stock option                
Stock option plan                
Granted (in shares)         740,350      
Granted (in dollars per share)         $ 51.33      
Forfeited (in shares)         357,052