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Stock award plan - Share-based Compensation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 70,325	$ 42,134	$ 33,252
Research and development
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	38,716	20,836	16,096
Selling, general and administrative
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 31,609	$ 21,298	$ 17,156

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
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-URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809

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-SubTopic 10
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-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

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+ References

No definition available.

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