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Revenue recognition - Net Product Sales (Details) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2020 USD ($)	Sep. 30, 2020 USD ($)	Jun. 30, 2020 USD ($)	Mar. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2020 USD ($) segment Distributor	Dec. 31, 2019 USD ($) Distributor	Dec. 31, 2018 USD ($) Distributor
Net product sales
Number of operating segments | segment									1
Revenue									$ 380,766	$ 306,980	$ 264,734
Number of distributors | Distributor									2	2	3
Contract with Customer, Liability	$ 4,200				$ 11,700				$ 4,200	$ 11,700
Contract Assets									0	0
Performance obligations satisfied in period									8,100	3,900
United States
Net product sales
Revenue									186,396	116,676
Non-US
Net product sales
Revenue									$ 194,370	$ 190,304
Maximum
Net product sales
Percentage of net product sales									10.00%	10.00%	10.00%
Net product revenue
Net product sales
Revenue	$ 107,258	$ 82,708	$ 75,239	$ 68,196	$ 81,407	$ 71,369	$ 85,476	$ 53,054	$ 333,401	$ 291,306	$ 263,005
Net product revenue | United States
Net product sales
Revenue									139,000	101,000	92,000
Net product revenue | Non-US
Net product sales
Revenue									$ 194,400	$ 190,300	$ 171,000

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Amount of decrease from sale of right to consideration in exchange for good or service transferred to customer when right is conditioned on something other than passage of time and other income.

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