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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	1 Months Ended				3 Months Ended							12 Months Ended
	Oct. 31, 2020 USD ($)	Aug. 31, 2020 USD ($)	Nov. 30, 2019 USD ($)	Nov. 30, 2011 USD ($) item	Dec. 31, 2020 USD ($)	Sep. 30, 2020 USD ($)	Mar. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($)
Collaboration and royalty revenue
Remaining potential milestones that can be achieved					$ 355,000							$ 355,000
Revenue												380,766	$ 306,980	$ 264,734
Collaboration revenue
Collaboration and royalty revenue
Revenue					7,516	$ 35,000	$ 63	$ 15,052	$ 47	$ 46	$ 529	42,579	15,674	1,729
Royalty revenue
Collaboration and royalty revenue
Revenue					4,090	$ 696						4,786
Licensing And Collaboration Agreement
Collaboration and royalty revenue
Performance period				2 years
Deferred consideration payable				$ 30,000
Licensing And Collaboration Agreement | Collaboration revenue
Collaboration and royalty revenue
Revenue												42,600	15,200	200
Licensing And Collaboration Agreement | Roche And SMA Foundation
Collaboration and royalty revenue
Collaborative arrangements number of compounds in preclinical development | item				3
Collaborative arrangements number of significant deliverables | item				2
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue												4,800	$ 0	$ 0
Research And Development Event Milestones | Licensing And Collaboration Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved					30,000							30,000
Milestone payments received	$ 7,500	$ 15,000	$ 15,000
Sales Milestones | Licensing And Collaboration Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved					$ 325,000							$ 325,000
Milestone payments received		$ 20,000
Maximum | Research And Development Event Milestones | Licensing And Collaboration Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved				$ 135,000

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