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v3.21.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2021 | Mar. 31, 2020
Cash flows from operating activities |  |
Net loss | $ (128,642) | $ (112,687)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 13,587 | 9,235
Non-cash operating lease expense | 1,819 | 1,330
Non-cash royalty revenue related to sale of future royalties | (2,858) |
Non-cash interest expense on liability related to sale of future royalties | 18,080 |
Change in valuation of deferred and contingent consideration | 100 | 900
Unrealized (gain) loss on ClearPoint Equity Investments | (6,764) | 1,574
Unrealized (gain) loss on ClearPoint convertible debt security | (7,858) | 2,799
Unrealized loss on marketable securities - equity investments | 302 |
Amortization of premiums (discounts) on investments, net | 1,359 | (333)
Amortization of debt issuance costs | 452 | 256
Share-based compensation expense | 25,707 | 15,220
Non-cash interest expense |  | 5,459
Unrealized foreign currency transaction gains, net | 24,691 | 8,675
Changes in operating assets and liabilities: |  |
Inventory, net | 1,963 | 102
Prepaid expenses and other current assets | 15,605 | (6,675)
Trade receivables, net | (25,010) | 2,346
Deposits and other assets | 136 | (192)
Accounts payable and accrued expenses | (28,756) | (4,000)
Other liabilities | (1,916) | (4,363)
Deferred revenue | (2,154) | (1,200)
Net cash used in operating activities | (100,157) | (81,554)
Cash flows from investing activities |  |
Purchases of fixed assets | (5,669) | (6,023)
Purchase of convertible debt security |  | (10,000)
Purchases of marketable securities - available for sale | (141,985) | (298,814)
Purchases of marketable securities - equity investments | (200,000) |
Sale and redemption of marketable securities- available for sale | 392,093 | 224,997
Acquisition of product rights and licenses | (14,192) | (11,434)
Purchase of equity investment in ClearPoint | (100) |
Net cash provided by (used in) investing activities | 30,147 | (101,274)
Cash flows from financing activities |  |
Proceeds from exercise of options | 11,755 | 9,987
Net proceeds from public offerings |  | 13,503
Repayment of senior secured term loan |  | (5,000)
Payment of finance lease principal | (2,224) |
Net cash provided by financing activities | 9,531 | 18,490
Effect of exchange rate changes on cash | (1,701) | (403)
Net decrease in cash and cash equivalents | (62,180) | (164,741)
Cash and cash equivalents, and restricted cash beginning of period | 216,312 | 295,528
Cash and cash equivalents, and restricted cash end of period | 154,132 | 130,787
Supplemental disclosure of cash information |  |
Cash paid for interest | 5,182 | 4,878
Cash paid for income taxes | 687 | 507
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized loss on marketable securities, net of tax | (1,294) | (63)
Right-of-use assets obtained in exchange for operating lease obligations | 13 | 22,642
Acquisition of product rights and licenses | $ 8,870 | $ 2,775

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