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Fair value of financial instruments and marketable securities - Hierarchy (Details) - USD ($) $ in Thousands | Mar. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | $ 642,077 | $ 894,838
Marketable securities - equity investments | 27,400 | 20,500
ClearPoint convertible debt security | 37,100 | 29,300
Contingent consideration payable | 240,500 | 240,400
Recurring basis |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint Equity Investments | 27,367 | 20,503
ClearPoint convertible debt security | 37,109 | 29,252
Recurring basis | Level 1 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint Equity Investments | 27,367 | 20,503
Recurring basis | Level 2 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint convertible debt security | 37,109 | 29,252
Recurring basis | Development and Regulatory Milestone |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 139,300 | 139,200
Recurring basis | Development and Regulatory Milestone | Level 3 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 139,300 | 139,200
Recurring basis | Net Sales Milestones and Royalties |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 101,200 | 101,200
Recurring basis | Net Sales Milestones and Royalties | Level 3 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 101,200 | 101,200
Recurring basis | Marketable securities |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | 642,077 | 894,838
Marketable securities - equity investments | 199,697 |
Recurring basis | Marketable securities | Level 1 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - equity investments | 199,697 |
Recurring basis | Marketable securities | Level 2 |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | $ 642,077 | $ 894,838

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