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Debt - (Tables)

3 Months Ended

Mar. 31, 2021

Debt Instrument, Redemption [Line Items]

Summary of liability for sale of future royalties

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​	​	​	​	​
​		Three Months Ended March 31,		​
Liability for sale of future royalties- (current and noncurrent)	​	2021		​
Beginning balance as of December 31, 2020	​	$	679,762	​
Less: Non-cash royalty revenue payable to RPI	​	​	(2,858)	​
Plus: Non-cash interest expense recognized	​	​	18,080	​
Ending balance	​	$	694,984	​
Effective interest rate as of March 31, 2021	​		10.6	%

1.50% Convertible senior notes due 2026

Debt Instrument, Redemption [Line Items]

Summary of convertible notes

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​	​	​	​	​	​	​
Liability component		March 31, 2021		​	December 31, 2020
Principal	​	$	287,500	​	$	287,500
Less: Debt issuance costs	​		(6,457)	​		(4,058)
Less: Debt discount, net(1)	​		—	​		(106,065)
Net carrying amount	​	$	281,043	​	$	177,377

Summary of interest expense recognized related to the Convertible Notes

​

​	​	​	​	​	​	​	​
​		​	​	​	​	​	​
​	​	Three Months Ended March 31,					​
​		2021			​	2020	​
Contractual interest expense	​	$	1,069	​	$	1,076	​
Amortization of debt issuance costs	​		277	​	​	124	​
Amortization of debt discount	​	​	—	​	​	3,234	​
Total	​	$	1,346	​	$	4,434	​
Effective interest rate of the liability component	​		1.9	%	​	10.2	%

3.00% Convertible senior notes due 2022

Debt Instrument, Redemption [Line Items]

Summary of convertible notes

​

​	​	​	​	​	​	​
​	​	​	​	​	​	​
​	​	​	​	​	​	​
Liability component		March 31, 2021			December 31, 2020
Principal	​	$	150,000	​	$	150,000
Less: Debt issuance costs	​		(1,005)	​		(865)
Less: Debt discount, net (1)	​		—	​		(17,372)
Net carrying amount	​	$	148,995	​	$	131,763

Summary of interest expense recognized related to the Convertible Notes

​

​	​	​	​	​	​	​	​
​	​	​	​	​	​	​
​	​	Three Months Ended March 31,
​		2021			2020
Contractual interest expense	​	$	1,110	​	$	1,119	​
Amortization of debt issuance costs	​		175	​		111	​
Amortization of debt discount	​		—	​		2,225	​
Total	​	$	1,285	​	$	3,455	​
Effective interest rate of the liability component	​		3.5	%		11.0	%

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Tabular disclosure of activity related to the liability resulting from the sale of future royalties.

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