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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 3 Months Ended
Jul. 17, 2020
USD ($)
Dec. 22, 2017
Mar. 31, 2021
USD ($)
segment
Mar. 31, 2020
USD ($)
Dec. 31, 2020
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Letters of Credit     $ 7,500    
Term for letter of credit (in years)     5 years    
Number of operating segments | segment     1    
Allowance for credit loss     $ 0 $ 0  
Increase in allowance for credit losses     0 0  
Allowance for doubtful accounts receivable     200   $ 100
Deferred payroll taxes provided for under CARES Act     2,500    
Cash consideration received from Royalty Purchase Agreement $ 650,000        
Federal income tax statutory rate   21.00%      
Deferred tax liability     122,000    
Fifth Anniversary          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Letters of Credit     3,800    
Non-US          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Net product revenue     47,800 40,700  
United States          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Net product revenue     $ 43,500 $ 27,500