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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Collaboration and royalty revenue
Revenue	$ 117,942	$ 68,259
Collaboration revenue
Collaboration and royalty revenue
Revenue	20,007	63
Royalty revenue
Collaboration and royalty revenue
Revenue	6,655	0
Licensing And Collaboration Agreement
Collaboration and royalty revenue
Revenue	20,000	100
Licensing And Collaboration Agreement | Collaboration revenue
Collaboration and royalty revenue
Revenue	20,000	100
Licensing And Collaboration Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue	6,700	0
Licensing And Collaboration Agreement | Sales Milestones
Collaboration and royalty revenue
Milestone payments received	$ 20,000	$ 0

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