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Summary of significant accounting policies - Liability for Sale of Future Royalties (Details) $ in Millions	Jul. 17, 2020 USD ($)
Assigned royalty payments
Cash consideration received from Royalty Purchase Agreement	$ 650.0
Assigned royalty payment, retained percentage	57.067%
Remaining potential milestones that can be achieved	$ 335.0
Royalty Purchase Agreement \| Assigned Royalty Payments
Assigned royalty payments
Assigned royalty payment, percentage	42.933%
Cash consideration received from Royalty Purchase Agreement	$ 650.0
Royalty purchase agreement, termination period	60 days
Royalty purchase agreement, payment maximum	$ 1,300.0