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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) $ in Thousands	Mar. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Mar. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Level 3 | Contingent Consideration Payable
Fair Value Valuation Inputs
Fair value	$ 139,300	$ 139,200	$ 273,900	$ 290,500
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	0		0
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 381,000		$ 381,000
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25		0.25
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94		0.94
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.015		0.022
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.049		0.045
Agilis | Development and Regulatory Milestone | Level 3 | Contingent Consideration Payable
Fair Value Valuation Inputs
Fair value	$ 139,300		$ 139,200
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0		0
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 150,000		$ 150,000
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25		0.25
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94		0.94
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.02		0.02
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.06		0.06
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.125		0.115
Agilis | Net Sales Milestones and Royalties | Level 3
Fair Value Valuation Inputs
Fair value	$ 101,200	$ 101,200	$ 83,300	$ 65,800
Agilis | Net Sales Milestones and Royalties | Level 3 | Contingent Consideration Payable
Fair Value Valuation Inputs
Fair value	$ 101,200		$ 101,200

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+ References

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- Definition

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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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