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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 24,859	$ 53,291
Income tax payable	3,909	4,315
Consulting and contracted research	23,927	18,250
Professional fees	4,685	3,614
Sales allowance	55,638	54,327
Sales rebates	49,665	63,774
Royalties	16,181	16,575
Accounts payable	19,114	18,665
Other	7,658	9,357
Accounts payable and accrued expenses	$ 205,636	$ 242,168

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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