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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Dec. 31, 2020
Jun. 30, 2016
May 31, 2013
Mar. 31, 2021
Mar. 31, 2020
Jan. 31, 2020
Stock option plan            
Share-based compensation expense       $ 25,707 $ 15,220  
Restricted stock            
Stock option plan            
Grants in period (in shares)       850,365    
Stock option            
Stock option plan            
Granted (in shares)       1,954,690    
Expected dividend yield (as a percent)       0.00%    
Weighted average grant date fair value (in dollars per share)       $ 46.90    
Risk-free interest rate (as a percent)       0.51%    
Expected volatility (as a percent)       88.61%    
Expected term (in years)       5 years 6 months    
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock            
Stock option plan            
Number of shares available for issuance       0    
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock | Maximum            
Stock option plan            
Number of shares subject to outstanding awards (in shares)     3,040,444      
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan | Common stock            
Stock option plan            
Number of shares available for issuance     122,296      
2013 Long Term Incentive Plan | Minimum            
Stock option plan            
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number     2,500,000      
Annual increase in the number of shares outstanding on the first day of the fiscal year     4.00%      
2013 Long Term Incentive Plan | Common stock            
Stock option plan            
Number of shares available for issuance       826,484    
2020 Inducement Stock Incentive Plan | Common stock            
Stock option plan            
Number of shares available for issuance       1,205,375    
Number of additional shares authorized (in shares) 1,000,000          
2020 Inducement Stock Incentive Plan | Common stock | Maximum            
Stock option plan            
Number of shares authorized (in shares)           1,000,000
2020 Inducement Stock Incentive Plan | Stock option            
Stock option plan            
Inducement grants for non-statutory stock options (in shares)       13,465    
Employee Stock Purchase Plan            
Stock option plan            
Number of shares authorized (in shares)   1,000,000        
Share-based compensation expense       $ 500    
Award requisite service period   6 months        
Purchase price of common stock, percent   85.00%        
Employee stock purchase plan, voting percentage limit   5.00%