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Stock award plan - Share Base Compensation (Details) - Stock option
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2021
USD ($)
$ / shares
shares
Number of options  
Outstanding at the beginning of the period (in shares) | shares 9,663,677
Granted (in shares) | shares 1,954,690
Exercised (in shares) | shares (415,783)
Forfeited/Cancelled (in shares) | shares (213,382)
Outstanding at the end of the period (in shares) | shares 10,989,202
Vested or Expected to vest at the end of the period (in shares) | shares 5,591,504
Exercisable at the end of the period (in shares) | shares 4,750,569
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) | $ / shares $ 38.72
Granted (in dollars per share) | $ / shares 66.49
Exercised (in dollars per share) | $ / shares 28.32
Forfeited/Cancelled (in dollars per share) | $ / shares 48.58
Outstanding at the end of the period (in dollars per share) | $ / shares 43.86
Vested or Expected to vest at the end of the period (in dollars per share) | $ / shares 48.46
Exercisable at the end of the period (in dollars per share) | $ / shares $ 37.14
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 7 months 2 days
Vested or Expected to vest at the end of the period 8 years 8 months 8 days
Exercisable at the end of the period 6 years 25 days
Aggregate intrinsic value (in thousands)  
Outstanding at the end of the period (in dollars) | $ $ 92,033
Vested or Expected to vest at the end of the period (in dollars) | $ 31,047
Exercisable at the end of the period (in dollars) | $ $ 58,970
Valuation assumptions  
Risk-free interest rate (as a percent) 0.51%
Expected volatility (as a percent) 88.61%
Expected term (in years) 5 years 6 months