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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands		1 Months Ended		3 Months Ended		12 Months Ended	31 Months Ended
	Apr. 20, 2017	Dec. 31, 2019	May 31, 2019	Mar. 31, 2021	Mar. 31, 2020	Dec. 31, 2019	Mar. 31, 2021	Dec. 31, 2020
Finite-Lived Intangible Assets
Amortization of acquired intangible assets				$ 11,278	$ 7,949
Total allocation of IPR&D assets				576,500
Change in indefinite-lived intangibles							$ 0
Goodwill				82,341			82,341	$ 82,341
Changes in goodwill				$ 0
Weighted Average
Finite-Lived Intangible Assets
Remaining amortization period				3 years 2 months 12 days
Agilis Merger Agreement | Akcea
Finite-Lived Intangible Assets
Milestone payments		$ 4,000	$ 6,000	$ 4,000		$ 6,000
Useful life		10 years	10 years
Emflaza asset acquisition
Finite-Lived Intangible Assets
Finite-lived intangibles	$ 148,400
Milestone obligation payments recorded				8,900	$ 2,800
Useful life	7 years
Emflaza asset acquisition | Accounts payable and accrued expenses
Finite-Lived Intangible Assets
Milestone payable				$ 8,900			$ 8,900

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Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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