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Revenue recognition - Narrative (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | ---
Mar. 31, 2021 USD ($) | Jun. 30, 2021 USD ($) Distributor | Jun. 30, 2020 USD ($) Distributor | Jun. 30, 2021 USD ($) segment Distributor | Jun. 30, 2020 USD ($) Distributor | Dec. 31, 2020 USD ($) | Nov. 30, 2011 USD ($)
Collaboration and royalty revenue |  |  |  |  |  |  |
Number of operating segments | segment |  |  |  | 1 |  |  |
Number of distributors | Distributor |  | 2 | 2 | 2 | 3 |  |
Contract with Customer, Liability |  |  |  |  |  | $ 4,200 |
Performance obligations satisfied in period |  | $ 1,900 | $ 2,000 | $ 4,000 | $ 4,000 |  |
Remaining potential milestones that can be achieved |  | 335,000 |  | 335,000 |  |  |
Revenue |  | 116,676 | 75,239 | 234,620 | 143,498 |  |
United States |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Net product revenue |  | 49,100 | 36,200 | 92,700 | 63,600 |  |
Non-US |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Net product revenue |  | $ 54,000 | $ 39,000 | $ 101,700 | $ 79,800 |  |
Minimum |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Percentage of net product sales threshold |  | 10.00% | 10.00% | 10.00% | 10.00% |  |
Collaboration revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | $ 0 | $ 0 | $ 20,007 | $ 63 |  |
Royalty revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 13,563 | 0 | 20,220 |  |  |
SMA License Agreement | Collaboration revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 0 | 0 | 20,000 | 100 |  |
SMA License Agreement | Royalty revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 13,600 | 0 | 20,200 | 0 |  |
SMA License Agreement | Roche And SMA Foundation | Collaboration revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 0 | $ 0 | 20,000 | 100 |  |
Research And Development Event Milestones | SMA License Agreement |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  | 10,000 |  | 10,000 |  |  |
Research And Development Event Milestones | SMA License Agreement | Maximum |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  | $ 135,000
Sales Milestones | SMA License Agreement |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  | 325,000 |  | 325,000 |  |  |
Milestone payments received | $ 20,000 | $ 0 |  | $ 20,000 | $ 0 |  |
Sales Milestones | SMA License Agreement | Maximum |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  | $ 325,000

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