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v3.21.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2021 | Jun. 30, 2020
Cash flows from operating activities |  |
Net loss | $ (247,012) | $ (294,114)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 28,573 | 19,445
Non-cash operating lease expense | 3,666 | 2,401
Non-cash finance lease amortization expense |  | 41,212
Non-cash royalty revenue related to sale of future royalties | (8,681) |
Non-cash interest expense on liability related to sale of future royalties | 38,083 |
Change in valuation of deferred and contingent consideration | 800 | 8,580
Settlement of deferred and contingent consideration |  | 10,613
Non-cash stock consideration, acquisition |  | 42,869
Unrealized (gain) loss on ClearPoint Equity Investments | (4,110) | 1,600
Unrealized (gain) loss on ClearPoint convertible debt security | (4,326) | 749
Unrealized gain on marketable securities - equity investments | (694) |
Non-cash interest expense |  | 10,993
Loss on disposal of asset |  | 26
Amortization of premiums (discounts) on investments, net | 2,644 | (635)
Amortization of debt issuance costs | 911 | 510
Share-based compensation expense | 51,406 | 32,130
Unrealized foreign currency transaction losses (gains), net | 15,983 | (3,248)
Changes in operating assets and liabilities: |  |
Inventory, net | 1,906 | 943
Prepaid expenses and other current assets | 15,649 | (16,569)
Trade receivables, net | (9,420) | 1,860
Deposits and other assets | (289) | (175)
Accounts payable and accrued expenses | (9,223) | (7,497)
Other liabilities | (3,083) | (4,132)
Deferred revenue | (4,085) | (3,925)
Net cash used in operating activities | (131,302) | (156,364)
Cash flows from investing activities |  |
Purchases of fixed assets | (13,643) | (8,183)
Purchase of convertible debt security |  | (10,000)
Purchases of marketable securities - available for sale | (192,931) | (367,102)
Purchases of marketable securities - equity investments | (200,000) |
Sale and redemption of marketable securities- available for sale | 514,716 | 428,490
Acquisition of product rights and licenses | (21,838) | (2,422)
Purchase of equity investment in ClearPoint | (100) |
Net cash provided by (used in) investing activities | 86,204 | 40,783
Cash flows from financing activities |  |
Proceeds from exercise of options | 13,144 | 25,045
Net proceeds from public offerings |  | 18,950
Repayment of senior secured term loan |  | (10,000)
Payments on deferred consideration obligation |  | (35,829)
Proceeds from employee stock purchase plan | 2,627 | 2,406
Payment of finance lease principal | (2,224) | (15,000)
Net cash provided by (used in) financing activities | 13,547 | (14,428)
Effect of exchange rate changes on cash | 86 | 442
Net decrease in cash and cash equivalents | (31,465) | (129,567)
Cash and cash equivalents, and restricted cash beginning of period | 216,312 | 295,528
Cash and cash equivalents, and restricted cash end of period | 184,847 | 165,961
Supplemental disclosure of cash information |  |
Cash paid for interest | 5,182 | 5,286
Cash paid for income taxes | 4,127 | 1,140
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain (loss) on marketable securities, net of tax | (1,369) | 2,655
Right-of-use assets obtained in exchange for operating lease obligations | 13 | 18,117
Right-of-use assets obtained in exchange for finance lease obligations |  | 41,212
Acquisition of product rights and licenses | $ 18,369 | 12,186
Issuance of common stock related to rights exchange |  | $ 150,528

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