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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | 34 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 20, 2017 | Dec. 31, 2019 | May 31, 2019 | Jun. 30, 2021 | Jun. 30, 2020 | Jun. 30, 2021 | Jun. 30, 2020 | Dec. 31, 2019 | Jun. 30, 2021 | Dec. 31, 2020 | Aug. 23, 2018
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |
Amortization of acquired intangible assets |  |  |  | $ 12,751 | $ 8,731 | $ 24,028 | $ 16,679 |  |  |  |
Total allocation of IPR&D assets |  |  |  |  |  | 576,500 |  |  |  |  |
Change in indefinite-lived intangibles |  |  |  |  |  |  |  |  | $ 0 |  |
Goodwill |  |  |  | 82,341 |  | 82,341 |  |  | 82,341 | $ 82,341 | $ 82,300
Changes in goodwill |  |  |  | 0 |  | $ 0 |  |  |  |  |
Weighted Average |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  |  |  |  | 2 years 10 months 24 days |  |  |  |  |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  | $ 4,000 | $ 6,000 |  |  | $ 4,000 |  | $ 6,000 |  |  |
Useful life |  | 10 years | 10 years |  |  |  |  |  |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangibles | $ 148,400 |  |  |  |  |  |  |  |  |  |
Milestone obligation payments recorded |  |  |  | 17,100 | $ 12,200 | 26,000 | $ 15,000 |  |  |  |
Useful life | 7 years |  |  |  |  |  |  |  |  |  |
Emflaza asset acquisition | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  | $ 18,400 |  | $ 18,400 |  |  | $ 18,400 |  |

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