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Stock award plan - (Tables)

6 Months Ended

Jun. 30, 2021

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2020		9,663,677	​	$	38.72				​	​
Granted		2,282,914	​	​	63.38				​	​
Exercised		(475,942)	​	​	27.66				​	​
Forfeited/Cancelled		(439,189)	​	​	53.85				​	​
Outstanding at June 30, 2021		11,031,460	​	$	43.70		7.34	years	​	$	64,268
Vested or Expected to vest at June 30, 2021		5,192,055	​	$	49.23		8.62	years	​	$	16,236
Exercisable at June 30, 2021		5,255,302	​	$	37.17		5.89	years	​	$	47,129

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​
​		Six months ended
​		June 30, 2021
Risk-free interest rate		0.51% - 0.96%
Expected volatility		85.94% - 88.61%
Expected term		5.5 years

Summary of information on the Company's restricted stock

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​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2020	​	982,058	​	$	41.78
Granted		951,558	​	​	64.21
Vested		(319,127)	​	​	35.21
Forfeited		(82,059)	​	​	57.75
Unvested at June 30, 2021		1,532,430	​	$	56.23

Schedule of share-based compensation expense recorded in the statement of operations

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Three Months Ended June 30,

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Six Months Ended June 30,

​

​

2021

2020

2021

2020

​

Research and development

​

$

13,443

​

$

8,562

​

$

27,168

​

$

16,741

​

Selling, general and administrative

​

12,256

​

8,348

​

24,238

​

15,389

​

Total

​

$

25,699

​

$

16,910

​

$

51,406

​

$

32,130

​

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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