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Debt - (Tables)

6 Months Ended

Jun. 30, 2021

Debt Instrument, Redemption [Line Items]

Summary of liability for sale of future royalties


		Six Months Ended June 30,
Liability for sale of future royalties- (current and noncurrent)		2021
Beginning balance as of December 31, 2020		$	679,762
Less: Non-cash royalty revenue payable to RPI			(8,681)
Plus: Non-cash interest expense recognized			38,083
Ending balance		$	709,164
Effective interest rate as of June 30 , 2021			11.5	%

1.50% Convertible senior notes due 2026

Debt Instrument, Redemption [Line Items]

Summary of convertible notes


Liability component		June 30, 2021			December 31, 2020
Principal		$	287,500		$	287,500
Less: Debt issuance costs			(6,179)			(4,058)
Less: Debt discount, net(1)			—			(106,065)
Net carrying amount		$	281,321		$	177,377

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended June 30,							Six Months Ended June 30,
		2021				2020			2021				2020
Contractual interest expense		$	1,066		$	1,066			$	2,135		$	2,142
Amortization of debt issuance costs			279			124				556			248
Amortization of debt discount			—			3,239				—			6,473
Total		$	1,345		$	4,429			$	2,691		$	8,863
Effective interest rate of the liability component			1.9	%		10.2	%			1.9	%		10.2	%

3.00% Convertible senior notes due 2022

Debt Instrument, Redemption [Line Items]

Summary of convertible notes




Liability component		June 30, 2021			December 31, 2020
Principal		$	150,000		$	150,000
Less: Debt issuance costs			(825)			(865)
Less: Debt discount, net (1)			—			(17,372)
Net carrying amount		$	149,175		$	131,763

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended June 30,						Six Months Ended June 30,
		2021			2020			2021			2020
Contractual interest expense		$	1,131		$	1,125		$	2,241		$	2,244
Amortization of debt issuance costs			180			114			355			225
Amortization of debt discount			—			2,295			—			4,520
Total		$	1,311		$	3,534		$	2,596		$	6,989
Effective interest rate of the liability component			3.5	%		11.0	%		3.5	%		11.0	%