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Leases - Narrative (Details) $ in Thousands		3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 19, 2020 room	Jun. 30, 2021 USD ($) ft² lease item	Jun. 30, 2020 USD ($)	Jun. 30, 2021 USD ($) ft² lease item	Jun. 30, 2020 USD ($)	Dec. 31, 2020 USD ($)
Leases
Number of operating leases | lease		3		3
Operating lease, expense		$ 5,200	$ 2,600	$ 10,600	$ 5,000
Aggregate rent, Initial term		137,232		137,232
2021 (excludes the six months ended June 30, 2021)		6,892		6,892
2022		13,314		13,314
Research and development		125,482	176,525	259,995	266,632
MassBio
Leases
Finance lease cost		$ 400	$ 0	$ 800	$ 0
Written notice required for early lease termination	24 months
Number of dedicated rooms provided for gene therapy AADC program | room	4
Finance lease, term of contract	12 years 6 months
Research and development						$ 41,400
Minimum
Leases
Operating lease, term of contract		6 months		6 months
Maximum
Leases
Operating lease, term of contract		14 years		14 years
Renewal Term		10 years		10 years
New Building | Minimum
Leases
Area of real estate property | ft²		75,000		75,000
Hopewell Campus
Leases
Operating lease, term of contract		15 years		15 years
Area of real estate property | ft²		220,500		220,500
Renewal Term		10 years		10 years
Number of renewable terms | item		2		2
Aggregate rent, Initial term		$ 111,500		$ 111,500
Percent of market rate		95.00%		95.00%
Mountainview
Leases
2021 (excludes the six months ended June 30, 2021)		$ 900		$ 900
2022		1,400		1,400
Thereafter		$ 0		$ 0

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Amount of lessee's undiscounted obligation for lease payment for operating lease due after first fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).

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The number of dedicated rooms provided for gene therapy AADC program under terms of the agreement.

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Term of lessee's operating lease renewal, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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