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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenues:        
Revenue $ 116,676 $ 75,239 $ 234,620 $ 143,498
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 7,358 5,304 16,462 9,389
Amortization of acquired intangible assets 12,751 8,731 24,028 16,679
Research and development 125,482 176,525 259,995 266,632
Selling, general and administrative 68,878 53,659 129,973 111,869
Change in the fair value of deferred and contingent consideration 700 7,680 800 8,580
Settlement of deferred and contingent consideration 0 10,613   10,613
Total operating expenses 215,169 262,512 431,258 423,762
Loss from operations (98,493) (187,273) (196,638) (280,264)
Interest expense, net (22,559) (5,379) (41,718) (11,021)
Other income (expense), net 3,170 11,309 (7,716) (2,523)
Loss before income tax expense (117,882) (181,343) (246,072) (293,808)
Income tax expense (488) (84) (940) (306)
Net loss attributable to common stockholders $ (118,370) $ (181,427) $ (247,012) $ (294,114)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 70,414,632 65,150,780 70,302,241 63,769,958
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share-basic and diluted (in dollars per share) $ (1.68) $ (2.78) $ (3.51) $ (4.61)
Net product revenue        
Revenues:        
Revenue $ 103,113 $ 75,239 $ 194,393 $ 143,435
Collaboration revenue        
Revenues:        
Revenue 0 0 20,007 $ 63
Royalty revenue        
Revenues:        
Revenue $ 13,563 $ 0 $ 20,220